Abstract
Proliferation and the state of adhesion molecules (E-cadherin, galectin-3) and estrogen and progesterone receptors were immunohistochemically analyzed in breast cancer biopsy specimens under conditions of c-erbB2 overexpression with and without gene amplification. It was hypothesized that c-erbB2 overexpression without gene amplification led to suppression of proliferation and “conservation” of tumor cell.
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References
H. Aberle, H. Schwartz, and R. Kemler, J. Cell. Biochem., 61, No. 4, 514–523 (1996).
J. Albanell, J. Codony, A. Rovira, et al., Adv. Exp. Med. Biol., 532, 253–268 (2003).
G. Damia and M. Broggini, Eur. J. Cancer, 40, No. 17, 2550–2559 (2004).
M. B. Jarpe, C. Widmann, C. Knall, et al., Oncogene, 17, No. 11, 1475–1482 (1998).
T. A. Jarvinen, M. Tanner, V. Rantanen, et al., Am. J. Pathol., 156, No. 3, 839–847 (2000).
C. A. Lange, J. K. Richer, T. Shen, and K. B. Horwitz, J. Biol. Chem., 273, No. 47, 31,308–31,316 (1998).
G. Orend, D. Hunter, and E. Ruoslahti, Oncogene, 16, No. 20, 2575–2583 (1998).
J. R. Reeves, J. J. Going, G. Smith, et al., J. Histochem. Cytochem., 44, No. 11, 1251–1259 (1996).
E. K. Rowinsky and R. C. Donehower, New Engl. J. Med., 332, No. 15, 1004–1014 (1995).
D. M. Scolnick and T. D. Hallazonetis, Nature, 406, No. 6794, 430–435 (2000).
B. St. Croix, C. Sheehan, J. W. Rak, et al., J. Cell. Biol., 142, No. 2, 557–571 (1998).
O. Tetsu and F. McCormick, Nature, 398, No. 6726, 422–426 (1999).
Z. E. Winters, R. D. Leek, M. J. Bradburn, et al., Breast Cancer Res., 5, No. 6, R242–R249 (2003).
W. Yang, K. S. Klos, X. Zhou, et al., Cancer, 98, No. 6, 1123–1130 (2003).
D. Yu, T. Jing, B. Liu, et al., Mol. Cell, 2, No. 5, 581–591 (1998).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 7, pp. 106–109, July, 2006
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Petrov, S.V., Raskin, G.A. & Khasanov, R.S. A new hypothesis on the role of c-erbB2 oncogene in the progress of breast cancer. Bull Exp Biol Med 142, 94–97 (2006). https://doi.org/10.1007/s10517-006-0301-2
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DOI: https://doi.org/10.1007/s10517-006-0301-2