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Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma

Bulletin of Experimental Biology and Medicine volume 142, pages 69–72 (2006)Cite this article

Abstract

We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-α-alanine, β-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3-[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.

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Affiliations

  1. Laboratory of Pharmacological Studies, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Russia

    I. V. Sorokina, T. G. Tolstikova, N. A. Zhukova, N. I. Petrenko, N. V. Uzenkova & E. E. Shul’ts

  2. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    N. A. Popova

Authors
  1. I. V. Sorokina
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  2. T. G. Tolstikova
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  3. N. A. Zhukova
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  4. N. I. Petrenko
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  5. N. V. Uzenkova
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  6. E. E. Shul’ts
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  7. N. A. Popova
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Corresponding author

Correspondence to I. V. Sorokina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 7, pp. 78–81, July, 2006

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Sorokina, I.V., Tolstikova, T.G., Zhukova, N.A. et al. Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma. Bull Exp Biol Med 142, 69–72 (2006). https://doi.org/10.1007/s10517-006-0294-x

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  • DOI: https://doi.org/10.1007/s10517-006-0294-x

Key Words

  • transplantable tumor
  • antitumor effect
  • antimetastatic effect
  • betulonic acid
  • 2-and 3-[3-oxo-20(29)-lupen-28-oilamino]-propionic acid