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Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome

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Abstract

We studied the effect of cannabinoid receptor agonists anandamide and WIN 55,212-2 on the central pain syndrome induced by intraspinal injection of penicillin sodium salt in rats. Cannabinoids suppressed allodynia and spontaneous attacks in rats with the central pain syndrome. The analgesic effect was most pronounced after intrathecal injection of cannabinoid receptor agonist in a dose of 100 µg in 10 µl. After systemic treatment the analgesic effect was produced by only WIN 55,212-2 in a dose of 1 mg/kg. WIN 55,212-2 was superior to anandamide by the duration and intensity of the effect on allodynia and spontaneous attacks.

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Authors and Affiliations

  1. Laboratory of Pathophysiology, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Russia

    M. L. Kukushkin, S. I. Igon’kina & M. V. Churyukanov

  2. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia

    M. Yu. Bobrov, V. V. Bezuglov & N. V. Gretskaya

  3. I. M. Setchenov Moscow Medical Academy, Ministry of Health of Russia, Russia

    V. V. Churyukanov

Authors
  1. M. L. Kukushkin
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  2. S. I. Igon’kina
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  3. M. V. Churyukanov
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  4. V. V. Churyukanov
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  5. M. Yu. Bobrov
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  6. V. V. Bezuglov
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  7. N. V. Gretskaya
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Corresponding author

Correspondence to M. L. Kukushkin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 7, pp. 47–50, July, 2006

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Kukushkin, M.L., Igon’kina, S.I., Churyukanov, M.V. et al. Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. Bull Exp Biol Med 142, 39–42 (2006). https://doi.org/10.1007/s10517-006-0286-x

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  • DOI: https://doi.org/10.1007/s10517-006-0286-x

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