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Effect of GABAergic and adrenergic agents on activity of Na+/K+ pump and Cl-cotransport in somatic muscle cells of earthworm Lumbricus Terrestris

  • Experimental Biology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

GABA, baclofen, epinephrine, and norepinephrine hyperpolarized the membrane of earthworm somatic cells. This effect was prevented by furosemide, removal of Cl from the medium, or activation of Na+/K+ pump by 3-fold increase external potassium concentration. It was hypothesized that GABA, baclofen, epinephrine, and norepinephrine stimulate Na+/K+ transport via specific receptor inputs, but their effect on resting potential can be realized only under conditions of working Cl symport.

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Correspondence to E. M. Volkov.

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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 141, No. 5, pp. 572–574, May, 2006

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Volkov, E.M., Sabirova, A.R., Nurullin, L.F. et al. Effect of GABAergic and adrenergic agents on activity of Na+/K+ pump and Cl-cotransport in somatic muscle cells of earthworm Lumbricus Terrestris . Bull Exp Biol Med 141, 633–635 (2006). https://doi.org/10.1007/s10517-006-0239-4

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  • DOI: https://doi.org/10.1007/s10517-006-0239-4

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