Abstract
The time course of morphofunctional changes in the liver, thymus, and spleen was observed in BALB/c mice with Con A-induced experimental hepatitis. The progress of alterative changes in the liver was paralleled by intensification of accidental involution of the thymus. On day 1 of hepatitis development high proliferative and cytostatic activity of splenocytes was paralleled by hemorrhagic necroses and depletion of the periarteriolar lymphoid sheaths in the spleen (T-zones), presumably due to migration of activated lymphocytes to the liver and barrier tissues. Later normalization of lymphocyte proliferative activity was paralleled by recovery and hyperplasia of the splenic T-cell zones.
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References
A. L. Rakhmilevich and S. S. Obernikhin, Immunologiya, No. 1, 68–69 (1990).
V. V. Serov, Z. G. Aprosina, P. E. Krel’, et al., Arkh. Patol., 66, No. 6, 6–11 (2004).
R. G. Batey and J. Wang, Front. Biosci., 1, No. 7, d1662–d1675 (2002).
H. Hentze, F. Ganter, S. Kolb, and A. Wendel, Am. J. Pathology, 156, No. 6, 2045–2056 (2000).
R. Ksontini, D. B. Cologiovanni, V. D. Josephs, et al., J. Immunol., 160, No. 8, 4082–4089 (1998).
F. Nicoletti, B. Beltrami E. Raschi, et al., Clin. Exp. Immunol., 110, No. 3, 479–484 (1997).
T. Okamoto, Y. Nakano, W. Asakura, et al., Jpn. J. Pharmacol., 77, 219–225 (1998).
L. Suntucci, S. Fiorucci, F. Cammilleri, et al., Hepatology, 31, No. 2, 399–406 (2000).
C. D. Surh and J. Sprent, J. Exp. Med., 192, No. 4, F9–F14 (2000).
H. Tsutsui, K. Adachi, E. Seki and K. Nakanishi, Curr. Mol. Med., 3, No. 6, 545–559 (2003).
A. Yamanaka, S. Hamano, Y. Miyazaki, et al., J. Immunol., 172, No. 6, 3590–3596 (2004).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 451–454, April, 2006
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Obernikhin, S.S., Makarova, O.V., Malaitsev, V.V. et al. Dynamics of morphofunctional changes in immune organs of BALB/c mice with experimental hepatitis. Bull Exp Biol Med 141, 465–467 (2006). https://doi.org/10.1007/s10517-006-0200-6
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DOI: https://doi.org/10.1007/s10517-006-0200-6