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Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors

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Abstract

Ten-minute perfusion of intact isolated rat heart with Krebs-Henseleit solution containing δ-opioid receptor agonists (DPDPE, (−)-TAN-67) or δ-opioid receptor antagonists (naltrindole, TIPP[Ψ], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the rates of myocardial contraction and relaxation. Intravenous injection of δ-agonists (DPDPE, (−)-TAN-67, deltorphin II) or δ-antagonists (naltrindole, TIPP[Ψ], ICI 174,864) decreased HR in narcotized rats. Naloxone and naltrexone produced no effect on contractility and HR both in vivo and in vitro. Preliminary injection of naloxone and naltrexone did not prevent the negative chronotropic effect of ICI 174,864 in vitro. The negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated by unknown non-opioid receptors in the heart.

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References

  1. T. V. Lasukova, L. N. Maslov, Yu. K. Podoksenov, et al., Byull. Eksp. Biol., 137, No. 1, 35–38 (2004).

    Google Scholar 

  2. Yu. B. Lishmanov and L. N. Maslov, Pat. Fiziol. Eksp. Ter., No. 1, 2–10 (2003).

  3. L. N. Maslov, Yu. B. Lishmanov, G. Calo, and L. Ma, Ibid., 66, No. 5, 59–68 (2003).

    CAS  Google Scholar 

  4. L. N. Maslov, Yu. B. Lishmanov, and G. N. Smagin, Eksp. Klin. Farmakol., 65, No. 2, 70–75 (2002).

    PubMed  CAS  Google Scholar 

  5. E. V. Navolotskaya, Yu. A. Kovalitskaya, Yu. A. Zolotarev, et al., Biokhimiya, 69, No. 8, 1071–1078 (2004).

    Google Scholar 

  6. J. L. Butour, C. Moisand, H. Mazarguil, et al., Eur. J. Pharmacol., 321, No. 1, 97–103 (1997).

    Article  PubMed  CAS  Google Scholar 

  7. T. Costa and A. Herz, Proc. Natl. Acad. Sci. USA, 86, 7321–7325 (1989).

    Article  PubMed  CAS  Google Scholar 

  8. B. N. Dhawan, F. Cesselin, R. Raghubir, et al., Pharmacol. Rev., 48, No. 4, 567–592 (1996).

    PubMed  CAS  Google Scholar 

  9. M. Dumont and S. Lemaire, J. Mol. Cell. Cardiol., 30, No. 12, 2751–2760 (1998).

    Article  PubMed  CAS  Google Scholar 

  10. P. J. Emmerson, M. R. Liu, J. H. Woods, and F. Medzihradsky, J. Pharmacol. Exp. Ther., 271, No. 3, 1630–1637 (1994).

    PubMed  CAS  Google Scholar 

  11. L. N. Maslov, Yu. B. Lishmanov, N. V. Solenkova, et al., Life Sci., 73, No. 7, 947–952 (2003).

    Article  PubMed  CAS  Google Scholar 

  12. R. J. Milne, J. M. Coddington, and G. D. Gamble, Neurosci. Lett., 114, No. 3, 250–264 (1990).

    Article  Google Scholar 

  13. B. P. Roques, G. Gacel, V. Dauge, et al., Neurophysiol. Clin., 20, No. 5, 369–387 (1990).

    PubMed  CAS  Google Scholar 

  14. G. E. Sander, R. F. Lowe, and T. O. Giles, Peptides, 7, No. 2, 259–265 (1986).

    Article  PubMed  CAS  Google Scholar 

  15. C. Ventura, L. Bastagli, P. Bernardi, et al., Biochem. Biophys. Acta, 987, No. 1, 69–74 (1989).

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. State Research Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia

    L. N. Maslov, Yu. B. Lishmanov, E. I. Barzakh & T. V. Lasukova

  2. Tomsk State Pedagogical University, Tomsk

    L. N. Maslov & E. I. Barzakh

  3. Laboratory of Medical Pathology, University of Kentucky College of Medicine, Lexington

    K. K. Rice

  4. Department of Pathology, University of Kentucky College of Medicine, Lexington

    P. R. Oeltgen

Authors
  1. L. N. Maslov
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  2. Yu. B. Lishmanov
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  3. E. I. Barzakh
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  4. T. V. Lasukova
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  5. K. K. Rice
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  6. P. R. Oeltgen
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Correspondence to L. N. Maslov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 404–407, April, 2006

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Maslov, L.N., Lishmanov, Y.B., Barzakh, E.I. et al. Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors. Bull Exp Biol Med 141, 420–423 (2006). https://doi.org/10.1007/s10517-006-0188-y

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  • DOI: https://doi.org/10.1007/s10517-006-0188-y

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