Skip to main content
SpringerLink
Log in

Regression analysis of relationship between liver weight and body weight after partial hepatectomy in rats

  • Methods
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A method for evaluation of the initial weight of the liver is developed for calculating the regeneration coefficient after partial hepatectomy on the basis of linear regression analysis. Experiments on rats showed that the model reflecting the relationship between liver weight and body weight for calculation of regeneration coefficient after partial resection of the liver expressed by the equation P 0=0.033×M can be used for screening of potential hepatoprotectors for quantitative evaluation of the regeneration processes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. O. Yu. Abakumova, N. G. Kutsenko, and L. M. Fedorova, Vestn. Rossiisk. Akad. Med. Nauk, No. 5, 36–41 (1996).

  2. A. Bryul’ and P. Tsefel’, SPSS Packet: Last Word for Analysis, Processing, and Presentation of Statistical Data in Marketing, Sociology, and Medicine [in Russian], Ed. by V. E. Molot, Moscow, St. Petersburg, Kiev (2002).

  3. A. I. Vengerovskii, I. V. Markova, and A. S. Saratikov, Manual on Experimental Preclinical Studies of New Drugs [in Russian], Ed. by V. P. Fisenko (2000), pp. 228–231.

  4. V. V. Gaivoronskaya, S. V. Okovityi, E. B. Shustov, and A. V. Smirnov, Eksp. Klin. Farmakol., 63, No. 5, 34–36 (2000).

    CAS  Google Scholar 

  5. S. D. Podymova, Liver Diseases. Manual for Physicians [in Russian], Moscow (1999).

  6. B. P. Salopaev, Regeneration, Adaptation, Homeostasis [in Russian], Gorky (1990).

  7. G. M. Higgins and R. M. Anderson, Arch. Pathol., 12, 188–202 (1931).

    Google Scholar 

  8. G. K. Michalopoulos and M. C. De Frances, Science, 267, 60–66 (1997).

    Article  Google Scholar 

  9. M. Rizetto, Ital. J. Gastroenterol. Hepatol., 31, 781–793 (1999).

    Google Scholar 

  10. L. Schiaffonati and L. Tiberio, Liver, 17, No. 4, 183–191 (1997).

    PubMed  CAS  Google Scholar 

  11. W. C. Verly, The Control of Liver Growth, New York (1976).

Download references

Author information

Authors and Affiliations

  1. Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    L. K. Khnychenko, I. I. Stepanov & N. S. Sapronov

Authors
  1. L. K. Khnychenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. I. Stepanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. S. Sapronov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 234–236, February, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khnychenko, L.K., Stepanov, I.I. & Sapronov, N.S. Regression analysis of relationship between liver weight and body weight after partial hepatectomy in rats. Bull Exp Biol Med 141, 269–271 (2006). https://doi.org/10.1007/s10517-006-0146-8

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0146-8

Key Words

Search

Navigation