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Delayed effects of enalapril on structural characteristics of the glomerular apparatus in the kidneys of NISAG rats

  • Physiology
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Abstract

Structural characteristics of renal glomeruli were studied in adult hypertensive NISAG rats (hereditary stress-induced hypertension) receiving antihypertensive drug enalapril, an inhibitor of angiotensin-converting enzyme, on days 28–58 of life. Treatment with enalapril (25 mg/kg perorally) in the early period of postnatal ontogeny produced delayed hypotensive and nephroprotective effects.

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References

  1. A. L. Markel’, Izv. Akad. Nauk SSSR, No. 3, 466–469 (1985).

    Google Scholar 

  2. M. D. Shmerling, E. E. Filyushina, V. A. Lazarev, et al., Byull. Eksp. Biol. Med., 131, No. 6, 713–716 (2001).

    Google Scholar 

  3. M. Adamczak, M. L. Gross, J. Krtil, et al., J. Am. Soc. Nephrol., 14, No. 11, 2833–2842 (2003).

    Article  PubMed  CAS  Google Scholar 

  4. K. Amann, C. Nichols, J. Tomig, et al., Nephrol. Dial. Transplant., 11, No. 6, 1003–1011 (1996).

    PubMed  CAS  Google Scholar 

  5. M. P. Dubrulle, F. Terzi, M. C. Gubler, et al., Am. J. Pathol., 141, No. 6, 1481–1489 (1992).

    PubMed  CAS  Google Scholar 

  6. S. A. Dukacz, M. A. Adams, and R. L. Kline, Am. J. Physiol., 276, No. 1, R10–R16 (1999).

    PubMed  CAS  Google Scholar 

  7. G. Guron, A. Nilsson, N. Niteseu, et al., Acta Physiol. Scand., 165, No. 1, 103–112 (1999).

    Article  PubMed  CAS  Google Scholar 

  8. T. M. Hale, M. Shoichet, T. L. Bushfield, et al., Hypertension, 42, No. 2, 171–176 (2003).

    Article  PubMed  CAS  Google Scholar 

  9. N. S. Kang, H. E. Yim, I. Bae, et al., Pediatr. Nephrol., 18, No. 9, 865–871 (2003).

    Article  PubMed  Google Scholar 

  10. J. M. Ledingham and R. Laverty, Clin. Exp. Pharmacol. Physiol. Suppl., 22, No. 1, S350–S352 (1995).

    PubMed  CAS  Google Scholar 

  11. A. B. Nilsson, M. A. Adams, S. J. Matthews, et al., Nephrol. Dial. Transplant., 13, No. 12, 3065–3073 (1998).

    Article  PubMed  CAS  Google Scholar 

  12. A. Remuzzi, S. Puntorieri, C. Battaglia, et al., J. Clin. Invest., 85, No. 2, 541–549 (1990).

    Article  PubMed  CAS  Google Scholar 

  13. N. Risler, C. Castro, M. Cruzado, et al., Am. J. Hypertens., 15, No. 5, 416–421 (2002).

    Article  PubMed  CAS  Google Scholar 

  14. N. K. Thybo, N. Korsgaard, S. Eriksen, et al., Hypertension, 23, No. 5, 659–666 (1994).

    PubMed  CAS  Google Scholar 

  15. M. Yamamoto, M. Fukui, I. Shou, et al., J. Clin. Lab. Anal., 11, No. 1, 53–62 (1997).

    Article  PubMed  CAS  Google Scholar 

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 124–127, February, 2006

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Filyushina, E.E., Shmerling, M.D., Lazarev, V.A. et al. Delayed effects of enalapril on structural characteristics of the glomerular apparatus in the kidneys of NISAG rats. Bull Exp Biol Med 141, 167–169 (2006). https://doi.org/10.1007/s10517-006-0118-z

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  • DOI: https://doi.org/10.1007/s10517-006-0118-z

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