Skip to main content
SpringerLink
Log in

Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Young and middle-aged CBA mice were injected with “street” heroin in increasing doses for 14 days. Volume density of perisinusoid argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), while the levels of spontaneous, LPS-and ConA-stimulated splenocyte proliferation decreased in young mice. Six months after heroin discontinuation further progress of liver fibrosis was observed in young mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. N. Filimonov, N. I. Gavrilova, E. A. Ol’khovikova, and V. A. Shkurupii, Konsilium (Novosibirsk), No. 2, 6–10 (2000).

  2. M. S. de Araujo, S. Guerret, F. Gerard, et al., Cell. Mol. Biol., 43, No. 4, 589–596 (1997).

    PubMed  Google Scholar 

  3. P. Govitrapong, T. Suttitum, N. Kotchabhakdi, and T. Uneklabh, J. Pharmacol. Exp. Ther., 286, No. 2, 883–889 (1998).

    CAS  PubMed  Google Scholar 

  4. M. P. Nair, S. A. Schwartz, R. Polasani, et al., Clin. Diagn. Lab. Immunol., 4, No. 2, 127–132 (1997).

    CAS  PubMed  Google Scholar 

  5. M. Nikolova, M. Liubomirova, A. Iliev, et al., Isr. Med. Assoc. J., 4, No. 11, Suppl., 908–910 (2002).

    PubMed  Google Scholar 

  6. D. M. Novick, R. W. Enlow, A. M. Gelb, et al., Gut, 26, No. 1, 8–13 (1985).

    CAS  PubMed  Google Scholar 

  7. R. Pacifici, S. Di Carlo, A. Bacosi, et al., Int. J. Immunopharmacol., 22, No. 8, 603–614 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. S. Schenker, R. R. Martin, and A. M. Hoyumpa, J. Hepatol., 31, 1098–1105 (1999).

    Article  CAS  PubMed  Google Scholar 

  9. I. Tegeder, J. Lotsch, and G. Geisslinger, Clin. Pharmacokinet., 37, No. 1, 17–40 (1999).

    Article  CAS  PubMed  Google Scholar 

  10. P. T. Thomas, R. V. House, and H. N. Bhargava, Gen. Pharmacol., 26, No. 1, 123–130 (1995).

    CAS  PubMed  Google Scholar 

  11. M. S. Triguero de Araujo, F. Gerard, P. Chossegros, et al., Virchows Arch. A. Pathol. Anat. Histopathol., 422, No. 2, 145–152 (1993).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Novosibirsk State Medical Academy, Russia

    P. N. Filimonov & N. I. Gavrilova

  2. Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Russia

    T. G. Sukhenko

  3. Research Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Russia

    V. A. Shkurupii

Authors
  1. P. N. Filimonov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. G. Sukhenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. N. Papantonopulo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. I. Gavrilova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. A. Shkurupii
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 140, No. 12, pp. 678–680, December, 2005

Municipal Clinical Hospital No. 12

Rights and permissions

Reprints and permissions

About this article

Cite this article

Filimonov, P.N., Sukhenko, T.G., Papantonopulo, A.N. et al. Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence. Bull Exp Biol Med 140, 723–725 (2005). https://doi.org/10.1007/s10517-006-0066-7

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0066-7

Key Words

Search

Navigation