Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 140, Issue 6, pp 705–707 | Cite as

Seasonal effects of Selank on the behavior of hibernating animals

  • T. P. SemenovaEmail author
  • M. M. Kozlovskaya
  • A. V. Zuikov
  • I. I. Kozlovskii
  • L. A. Andreeva
Article

Abstract

We studied the seasonal effects of peptide preparation Selank on orientation and exploratory activity in 36 arctic ground squirrels Citellus undulatus in the open-field and hole-board tests. Selank most significantly increased behavioral activity of hibernating animals in the spring and fall. The test peptide had no effect on locomotor activity of animals. The selective stimulatory effect of Selank on exploratory behavior of hibernating animals was season-dependent. The maximum effect was observed under conditions of seasonal depression-like state.

Key Words

Selank exploratory behavior stimulatory component of activity spectrum hibernating animals seasonal effects 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    I. A. Anoshkina, T. P. Semenova, L. P. Dolgacheva, and S. G. Kolaeva, Neirokhimiya, 20, 259–264 (2003).Google Scholar
  2. 2.
    A. I. Anufriev and A. K. Akhrimenko, Ecological and Physiological Characteristics of Natural Hypometabolic States [in Russian], Pushchino (1992), pp. 34–38.Google Scholar
  3. 3.
    E. B. Arushanyan, Chronopharmacology [in Russian], Stavropol (2000).Google Scholar
  4. 4.
    M. M. Kozlovskaya, I. I. Kozlovskii, E. A. Val’dman, and S. B. Seredenin, Fiziol. Zh., No. 4, 264–268 (2002).Google Scholar
  5. 5.
    T. P. Semenova, Optimization of Learning and Memory [in Russian], Pushchino (1992).Google Scholar
  6. 6.
    T. P. Semenova, Zh. Vyssh. Nervn. Deyat., 53, No. 2, 358–361 (2002).Google Scholar
  7. 7.
    S. B. Seredenin, M. M. Kozlovskaya, Yu. A. Blednov, et al., Ibid., 48, No. 1, 153–160 (1998).Google Scholar
  8. 8.
    S. B. Seredenin, T. P. Semenova, M. M. Kozlovskaya, et al., Khim.-Farm. Zh., 30, No. 5, 12–14 (1996).Google Scholar
  9. 9.
    E. A. Gromova, A. R. Chubakov, and T. P. Semenova, Signal Molecules and Mechanisms of Animal Behavior, Eds. W. Winlow et al., New York (1991), pp. 290–293 (1991).Google Scholar
  10. 10.
    F. Nurnberger, Cell Tissue Res., 281, 391–412 (1995).PubMedGoogle Scholar
  11. 11.
    N. K. Popova, T. P. Voronova, and A. V. Kulikov, Pharmacol. Biochem. Behav., 46, 9–13 (1993).CrossRefPubMedGoogle Scholar
  12. 12.
    T. P. Semenova, I. A. Anoshkina, B. M. Khomut, and S. G. Kolaeva, Behav. Processes, 56, 195–200 (2001).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • T. P. Semenova
    • 1
    Email author
  • M. M. Kozlovskaya
    • 2
  • A. V. Zuikov
    • 1
  • I. I. Kozlovskii
    • 2
  • L. A. Andreeva
    • 3
  1. 1.Institute of Cell BiophysicsRussian Academy of SciencesPushchino
  2. 2.V. V. Zakusov Institute of PharmacologyRussian Academy of Medical SciencesRussia
  3. 3.Institute of Molecular GeneticsRussian Academy of SciencesMoscow

Personalised recommendations