Bulletin of Experimental Biology and Medicine

, Volume 140, Issue 6, pp 705–707 | Cite as

Seasonal effects of Selank on the behavior of hibernating animals

  • T. P. SemenovaEmail author
  • M. M. Kozlovskaya
  • A. V. Zuikov
  • I. I. Kozlovskii
  • L. A. Andreeva


We studied the seasonal effects of peptide preparation Selank on orientation and exploratory activity in 36 arctic ground squirrels Citellus undulatus in the open-field and hole-board tests. Selank most significantly increased behavioral activity of hibernating animals in the spring and fall. The test peptide had no effect on locomotor activity of animals. The selective stimulatory effect of Selank on exploratory behavior of hibernating animals was season-dependent. The maximum effect was observed under conditions of seasonal depression-like state.

Key Words

Selank exploratory behavior stimulatory component of activity spectrum hibernating animals seasonal effects 


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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • T. P. Semenova
    • 1
    Email author
  • M. M. Kozlovskaya
    • 2
  • A. V. Zuikov
    • 1
  • I. I. Kozlovskii
    • 2
  • L. A. Andreeva
    • 3
  1. 1.Institute of Cell BiophysicsRussian Academy of SciencesPushchino
  2. 2.V. V. Zakusov Institute of PharmacologyRussian Academy of Medical SciencesRussia
  3. 3.Institute of Molecular GeneticsRussian Academy of SciencesMoscow

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