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Function of Hemopoietic Stem Cells under Conditions of Cytostatic Myelosuppression and Treatment with Hemostimilators

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We compared the function of hemopoietic stem cells under conditions of cytostatic myelosuppression (cyclophosphamide treatment) and during treatment with granulocytopoiesis stimulators. It was found that unipotent hemopoietic precursor cells are most sensitive to cyclophosphamide. Different effects of hemostimulators on stem cells are determined by different proportions between proliferation and differentiation processes.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk, Russia

    V. V. Zhdanov, L. A. Gur'yantseva, E. V. Udut, T. Yu. Khrichkova, E. V. Simanina & V. E. Gol'dberg

  2. Institute of Oncology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk, Russia

    V. V. Zhdanov, L. A. Gur'yantseva, E. V. Udut, T. Yu. Khrichkova, E. V. Simanina & V. E. Gol'dberg

Authors
  1. V. V. Zhdanov
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  2. L. A. Gur'yantseva
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  3. E. V. Udut
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  4. T. Yu. Khrichkova
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  5. E. V. Simanina
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  6. V. E. Gol'dberg
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__________

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 230–233, November, 2005

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Zhdanov, V.V., Gur'yantseva, L.A., Udut, E.V. et al. Function of Hemopoietic Stem Cells under Conditions of Cytostatic Myelosuppression and Treatment with Hemostimilators. Bull Exp Biol Med 140, 631–634 (2005). https://doi.org/10.1007/s10517-006-0041-3

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  • DOI: https://doi.org/10.1007/s10517-006-0041-3

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