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Pharmacological Regulation of Functional Activity of Stem Cells in Restoration of the Myocardium during the Postinfarction Period

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of granulocytic CSF on myocardial tissue recovery after acute myocardial infarction was studied on rats. A course of granulocytic CSF after ligation of the left coronary artery normalized ECG parameters and morphological picture of the myocardium 1 month after treatment. It was shown on mouse model of myocardial infarction that this process was associated with more intensive mobilization and homing of mesenchymal stem cells in the heart.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk, Russia

    L. A. Stavrova, T. I. Fomina, M. B. Plotnikov, O. I. Aliev, N. V. Sotnikova, O. I. Epstein, S. A. Sergeeva, L. A. Gur'yantseva, G. N. Zyuz'kov, V. V. Zhdanov, A. M. Dygai & E. G. Gol'dberg

  2. Materia Medica Holding, Russia

    L. A. Stavrova, T. I. Fomina, M. B. Plotnikov, O. I. Aliev, N. V. Sotnikova, O. I. Epstein, S. A. Sergeeva, L. A. Gur'yantseva, G. N. Zyuz'kov, V. V. Zhdanov, A. M. Dygai & E. G. Gol'dberg

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  1. L. A. Stavrova
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  2. T. I. Fomina
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  3. M. B. Plotnikov
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  4. O. I. Aliev
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  5. N. V. Sotnikova
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  6. O. I. Epstein
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  7. S. A. Sergeeva
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  8. L. A. Gur'yantseva
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  9. G. N. Zyuz'kov
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  10. V. V. Zhdanov
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  11. A. M. Dygai
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  12. E. G. Gol'dberg
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__________

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 190–194, November, 2005

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Stavrova, L.A., Fomina, T.I., Plotnikov, M.B. et al. Pharmacological Regulation of Functional Activity of Stem Cells in Restoration of the Myocardium during the Postinfarction Period. Bull Exp Biol Med 140, 593–597 (2005). https://doi.org/10.1007/s10517-006-0033-3

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  • DOI: https://doi.org/10.1007/s10517-006-0033-3

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