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Proteolysis of Apoprotein B-100 Impairs Its Topography on LDL Surface and Reduces LDL Association Resistance

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Abstract

Serine proteinases (trypsin and chymotrypsin) cause destruction of apolipoprotein B-100 on the surface of human blood LDL. Incubation of LDL with these enzymes increases the mean size of LDL particles. Proteolysis of apolipoprotein B-100 induces changes in surface structure, destabilizes LDL particles, and reduces their association resistance. Presumably, this proteolytic modification of LDL with subsequent association of these particles plays an important role in accumulation of cholesterol in the vascular wall and in the development of early stages of atherosclerosis.

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Authors and Affiliations

  1. Laboratrory of Atherogenesis Mechanisms, Institute of Experimental Cardiology, National Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    O. M. Panasenko, I. V. Suprun & I. A. Sobenin

  2. Laboratory of Cell Engineering, Institute of Experimental Cardiology, National Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    E. V. Yanushevskaya & T. N. Vlasik

  3. Laboratory of Physico-Chemical Methods of Investigation and Analysis, Institute of Physico-Chemical Medicine, Ministry of Health of the Russian Federation, Moscow, Russia

    O. M. Panasenko & A. A. Mel'nichenko

  4. Laboratory of Cell-Cell Interactions, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia

    D. V. Aksenov, I. A. Sobenin & A. N. Orekhov

  5. Institute of Atherosclerosis, Russian Academy of Natural Sciences, Moscow, Russia

    A. N. Orekhov

Authors
  1. O. M. Panasenko
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  2. D. V. Aksenov
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  3. A. A. Mel'nichenko
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  4. I. V. Suprun
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  5. E. V. Yanushevskaya
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  6. T. N. Vlasik
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  7. I. A. Sobenin
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  8. A. N. Orekhov
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Correspondence to O. M. Panasenko.

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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 11, pp. 530–534, November, 2005

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Panasenko, O.M., Aksenov, D.V., Mel'nichenko, A.A. et al. Proteolysis of Apoprotein B-100 Impairs Its Topography on LDL Surface and Reduces LDL Association Resistance. Bull Exp Biol Med 140, 521–525 (2005). https://doi.org/10.1007/s10517-006-0013-7

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  • DOI: https://doi.org/10.1007/s10517-006-0013-7

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