Skip to main content

Effect of Betulonic Acid and Its Derivative [3-Oxo-20(29)-Lupene-28-Oyl]-3-Aminopropionic Acid on Liver Structure in Mice with RLS Lymphoma

Abstract

Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions.

This is a preview of subscription content, access via your institution.

REFERENCES

  1. G. G. Avtandilov, Medical Morphometry [in Russian], Moscow (1990).

  2. T. A. Bogush, Microsomal Liver Oxidases and Effects of Antitumor Drugs [in Russian], Moscow (1983), pp. 26–32.

  3. M. L. Gershanovich, V. A. Filov, M. A. Akimov, and A. A. Akimov, Introduction in Drug Therapy of Malignant Tumors [in Russian], St. Petersburg (1999).

  4. O. R. Grek, S. V. Mishenina, and A. B. Pupyshev, Byull. Eksp. Biol. Med., 134, No.10, 413–417 (2002).

    Google Scholar 

  5. A. Yu. Grishanova, V. I. Kaledin, T. V. Zueva, et al., Vopr. Med. Khim., 49, No.1, 27–34 (2003).

    CAS  Google Scholar 

  6. Le Bang Shon, G. A. Posypanova, L. G. Kolibaba, et al., Vopr. Biol. Med. Farmatsevt. Khim., No. 4, 31–34 (2002).

  7. N. I. Petrenko, N. V. Elantseva, V. Z. Petukhova, et al., Khim. Prirod. Soed., No. 4, 276–283 (2002).

  8. V. V. Serov and K. Lapish, Morphological Diagnosis of Liver Diseases [in Russian], Moscow (1989).

  9. I. V. Sorokina, T. G. Tolstikova, E. B. Bubnova, et al., Nauch. Vestnik Tyumensk. Med. Akad., Bioantioxidants, No. 1, 60–61 (2003).

  10. I. V. Sorokina, T. G. Tolstikova, N. A. Zhukova, et al., Dokl. Akad. Nauk, 399, 274–277 (2004).

    Google Scholar 

  11. H. J. Jeong, H. B. Chai, S. Y. Park, and D. S. Kim, Bioorg Med. Chem. Lett., No. 9, 1201–1204 (1999).

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to I. V. Sorokina.

Additional information

__________

Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 9, pp. 348–351, September, 2005

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zhukova, N.A., Semenov, D.E., Sorokina, I.V. et al. Effect of Betulonic Acid and Its Derivative [3-Oxo-20(29)-Lupene-28-Oyl]-3-Aminopropionic Acid on Liver Structure in Mice with RLS Lymphoma. Bull Exp Biol Med 140, 361–364 (2005). https://doi.org/10.1007/s10517-005-0490-0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-005-0490-0

Key Words

  • polychemotherapy
  • liver
  • hepatoprotective effect
  • betulonic acid
  • [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid