Abstract
We found that gestosis is associated with platelet hypersensitivity to ADP. Cell P2X1 receptors exhibited a positive cooperative response to ADP (EC50=10.88±3.70 nM, Hill constant n=2.59±0.50 rel. units). Cooperative binding of ADP to platelet P2X1 receptors was also observed during incubation of cells from pregnant women with isosorbide dinitrate.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 9, pp. 261–264, September, 2005
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Shabanova, E.Y., Mindukshev, I.V., Malakhovskaya, E.A. et al. Cooperative Type of Platelet Hypersensitivity to ADP. Bull Exp Biol Med 140, 282–284 (2005). https://doi.org/10.1007/s10517-005-0467-z
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DOI: https://doi.org/10.1007/s10517-005-0467-z