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Effect of Ubiquinone Q10 and Antioxidant Vitamins on Free Radical Oxidation of Phospholipids in Biological Membranes of Rat Liver

Bulletin of Experimental Biology and Medicine volume 140, pages 181–183 (2005)Cite this article

Abstract

We studied the effects of 30-day peroral treatment with β-carotene, a complex of antioxidant vitamins (vitamins C and E and provitamin A) and selenium, and solubilized ubiquinone Q10 on the antioxidant potential in rat liver (ascorbate-dependent free radical oxidation of unsaturated membrane phospholipids). β-Carotene irrespective of the administration route increased antioxidant potential of the liver by 2–3.5 times. The complex of antioxidant vitamins and selenium increased this parameter by more than 15 times. Antiradical activity in rat liver was extremely high after administration of solubilized ubiquinone Q10 (increase by more than by 36 times). It can be expected that reduced ubiquinone Q10 in vivo should produce a more pronounced protective effect due to activity of the system for bioregeneration of this natural antioxidant.

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Affiliations

  1. A. L. Myasnikov Institute of Cardiology, Russian Ministry of Health, Moscow, Russia

    A. K. Tikhaze, G. G. Konovalova, V. Z. Lankin, A. I. Kaminnyi, V. I. Kaminnaja & V. V. Kukharchuk

  2. Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex, Russian Ministry of Health, Moscow, Russia

    E. K. Ruuge

Authors
  1. A. K. Tikhaze
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  2. G. G. Konovalova
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  3. V. Z. Lankin
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  4. A. I. Kaminnyi
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  5. V. I. Kaminnaja
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  6. E. K. Ruuge
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  7. V. V. Kukharchuk
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 8, pp. 146–149, August, 2005

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Tikhaze, A.K., Konovalova, G.G., Lankin, V.Z. et al. Effect of Ubiquinone Q10 and Antioxidant Vitamins on Free Radical Oxidation of Phospholipids in Biological Membranes of Rat Liver. Bull Exp Biol Med 140, 181–183 (2005). https://doi.org/10.1007/s10517-005-0439-3

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  • DOI: https://doi.org/10.1007/s10517-005-0439-3

Key Words

  • free radical lipid oxidation
  • ubiquinone Q10
  • antioxidant vitamins
  • tissue antioxidant potential