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Interspecies Pharmacokinetics of Xymedon

Bulletin of Experimental Biology and Medicine volume 140, pages 58–60 (2005)Cite this article

Abstract

Pharmacokinetics of immunomodulator xymedon at different modes of the drug administration was studied in humans, dogs, and rats. The main parameters of xymedon pharmacokinetics varied in different animal species. The results confirmed the efficiency and correctness of using allometrical method for extrapolation of pharmacokinetic data for tentative evaluation of drug parameters in humans by the results of preclinical trials on animals.

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Affiliations

  1. Kazan State Medical University, Kazan, Russia

    V. I. Pogorel'tsev, S. Yu. Garmonov, O. V. Polekhina & V. S. Reznik

  2. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences, Kazan, Russia

    V. I. Pogorel'tsev, S. Yu. Garmonov, O. V. Polekhina & V. S. Reznik

  3. Kazan State Technological University, Kazan, Russia

    V. I. Pogorel'tsev, S. Yu. Garmonov, O. V. Polekhina & V. S. Reznik

Authors
  1. V. I. Pogorel'tsev
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  2. S. Yu. Garmonov
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  3. O. V. Polekhina
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  4. V. S. Reznik
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 7, pp. 68–71, July, 2005

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Pogorel'tsev, V.I., Garmonov, S.Y., Polekhina, O.V. et al. Interspecies Pharmacokinetics of Xymedon. Bull Exp Biol Med 140, 58–60 (2005). https://doi.org/10.1007/s10517-005-0411-2

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  • DOI: https://doi.org/10.1007/s10517-005-0411-2

Key Words

  • xymedon pharmacokinetics
  • allometrical method