Abstract
Reductase activity of 17β-hydroxysteroid oxidoreductase in biopsy specimens of prostatic cancer and benign hyperplasia, and prostatic intraepithelial neoplasia and serum concentrations of testosterone, 5α-dihydrotestosterone, 4-androstene-3,17-dione were compared in patients and healthy individuals. Reductase activities of 17β-hydroxysteroid oxidoreductase in soluble fraction of prostatic biopsy specimens decreased in the following order: prostatic cancer>prostatic intraepithelial neoplasia>>benign prostatic hyperplasia. No differences in serum concentrations of testosterone, 5α-dihydrotestosterone, 4-androstene-3,17-dione between these three groups of patients were found, while the mean serum concentration of these androgens in patients with prostatic tumors did not surpass the threshold normal values for men. Hence, high reductase activity of 17β-hydroxysteroid oxidoreductase can be associated with pathogenetic mechanisms of human malignant prostatic tumors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 6, pp. 684–687, June, 2005
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Degtyar’, V.G., Babkina, T.V., Kazantseva, I.A. et al. Reductase Activity of 17β-Hydroxysteroid Oxidoreductase in Prostatic Tumors of Different Histological Structure. Bull Exp Biol Med 139, 715–717 (2005). https://doi.org/10.1007/s10517-005-0387-y
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DOI: https://doi.org/10.1007/s10517-005-0387-y