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Early Postnatal Effects of Noopept and Piracetam on Declarative and Procedural Memory of Adult Male and Female Rats


We studied the effect of a new nootropic dipeptide Noopept and reference nootropic preparation piracetam injected subcutaneously on days 8–20 of life on learning of alternative feeding response in a 6-arm-maze in male and female rats. Early postnatal administration of Noopept disturbed the dynamics of learning by parameters of declarative and procedural memory. Piracetam impaired learning by parameters of procedural, but not declarative memory (only in males). Both preparations decreased the ratio of successfully learned males (but not females). The observed effects were not associated with changes in locomotor activity.

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Correspondence to S. S. Trofimov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 6, pp. 651–655, June, 2005

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Trofimov, S.S., Voronina, T.A. & Guzevatykh, L.S. Early Postnatal Effects of Noopept and Piracetam on Declarative and Procedural Memory of Adult Male and Female Rats. Bull Exp Biol Med 139, 683–687 (2005).

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Key Words

  • nootropic agents
  • peptides
  • piracetam
  • Noopept
  • ontogeny