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Inotropic Response of the Myocardium in Rats with Postinfarction Cardiosclerosis Exposed to Extrasystolic Treatment

Bulletin of Experimental Biology and Medicine volume 139, pages 647–650 (2005)Cite this article

Abstract

The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions in the remodeled myocardium far surpassed the control. However, the amplitude of postextrasystolic contraction did not surpass that in normal contraction—relaxation cycle. Our results suggest that the ability of the sarcoplasmic reticulum in cardiomyocytes to accumulate Ca2+ is impaired during postinfarction remodeling.

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Affiliations

  1. Institute of Cardiology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk, Russia

    D. S. Kondrat’eva, S. A. Afanas’ev, L. P. Falaleeva & V. P. Shakhov

Authors
  1. D. S. Kondrat’eva
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  2. S. A. Afanas’ev
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  3. L. P. Falaleeva
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  4. V. P. Shakhov
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Corresponding author

Correspondence to D. S. Kondrat’eva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 6, pp. 613–616, June, 2005

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Kondrat’eva, D.S., Afanas’ev, S.A., Falaleeva, L.P. et al. Inotropic Response of the Myocardium in Rats with Postinfarction Cardiosclerosis Exposed to Extrasystolic Treatment. Bull Exp Biol Med 139, 647–650 (2005). https://doi.org/10.1007/s10517-005-0367-2

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  • DOI: https://doi.org/10.1007/s10517-005-0367-2

Key Words

  • sarcoplasmic reticulum
  • myocardium
  • rats
  • postinfarction cardiosclerosis