Abstract
The paper presents the results of a controlled study of cell therapy in 30 patients with severe forms of cerebral palsy. A cell suspension from immature nervous and hemopoietic tissues was injected into the subarachnoidal space of a recipient through a spinal puncture. Immune sensitization to donor antigens (detected by suppression of lymphocyte migration) was noted in few patients. In none patients laboratory and clinical signs of tissue-destructive autoimmune reactions were observed. One year after treatment activity of the major psychomotor functions in treated patients considerably surpassed the normal. No delayed complications of cell therapy were noted. These findings suggest that cell therapy is an effective, safe, and immunologically justified method of therapy for patients with cerebral palsy.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 84–88, 2005
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Seledtsov, V.I., Kafanova, M.Y., Rabinovich, S.S. et al. Cell Therapy of Cerebral Palsy. Bull Exp Biol Med 139, 499–503 (2005). https://doi.org/10.1007/s10517-005-0330-2
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DOI: https://doi.org/10.1007/s10517-005-0330-2