Abstract
We studied the effect of photodynamic therapy with photoditasine at different protocols of photoenergy exposure on morphofunctional parameters of M-1 sarcoma. It was found that proliferative activity of tumor cells (evaluated by immunostaining for PCNA) nonlinearly decreases after exposure to 150, 300, and 600 J/cmp2. The main form of cell death during the early period after photodynamic therapy was direct photocoagulation necrosis caused by destruction of sensitized cell structures and ischemic necrosis developing as a result of alteration of vascular network in the tumors. Photoenergy density was not essential for the intensity of induced apoptosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Yu. S. Romanko, A. F. Tsyb, M. A. Kaplan, and V. V. Popuchiev, Byull. Exp. Biol. Med., 136, No.12, 658–664 (2004).
Yu. F. Stranadko, Clinical Use of Low-Intensive Lasers [in Russian], Moscow (1997), pp. 173–184.
V. V. Yuzhakov, V. Kh. Khavinson, I. M. Kvetnoi, et al., Vopr. Onkol., 47, 328–334 (2001).
T. M. Busch, S. M. Hahn, S. M. Evans, and C. J. Koch, Cancer Res., 60, No.10, 2636–2642 (2000).
S. Coutier, L. N. Bezdetnaya, T. H. Foster, et al., Radiat. Res., 158, No.3, 339–345 (2002).
D. E. Dolmans, A. Kadambi, and J. S. Hill, Cancer Res., 62, No.15, 4289–4294 (2002).
T. J. Dougherty, C. J. Gomer, B. W. Henderson, et al., J. Natl. Cancer Inst., 90, No.12, 889–905 (1998).
A. Ferrario, K. F. von Tiehl, N. Rucker, et al., Cancer Res., 60, No.15, 4066–4069 (2000).
S. O. Gollnick, S. S. Evans, H. Baumann, et al., Br. J. Cancer, 88, No.11, 1772–1779 (2003).
M. Korbelik and I. Cecic, Cancer Lett., 137, No.1, 91–98 (1999).
M. D. Mason, Rev. Contemp. Pharmacother., 10, No.1, 25–37 (1999).
M. Mori, I. Sakata, T. Hirano, et al., Jpn. J. Cancer Res., 91, No.7, 753–759 (2000).
B. W. Pogue, B. Ortel, N. Chen, et al., Cancer Res., 61, No.2, 717–724 (2001).
K. Smetana, H. Cajthamlova, D. Grebenova, and Z. Hrkal, J. Photochem. Photobiol. B., 59, No.1–3, 80–86 (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 4, pp. 456–461, April, 2005
Rights and permissions
About this article
Cite this article
Romanko, Y.S., Tsyb, A.F., Kaplan, M.A. et al. Relationship between Antitumor Efficiency of Photodynamic Therapy with Photoditasine and Photoenergy Density. Bull Exp Biol Med 139, 460–464 (2005). https://doi.org/10.1007/s10517-005-0322-2
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0322-2