Abstract
Secretion of some IL and growth factors (VEGF, IGF-I, TGFβ) by endometrial tissues and endometrioid heterotopies was studied in vitro in patients with external genital endometriosis of different severity. The production of IL-1β, IL-2, IL-6, and VEGF in the endometrium increased in severe external genital endometriosis, while the secretion of TGFβ decreased; hyperproduction of IL-2, IL-6, VEGF and decreased production of TGFβ were detected in endometrioid foci. Presumably, local cytokine imbalance and increased proliferative activity of endometrial cells are involved in the mechanisms of formation and functioning of endometrioid foci.
Similar content being viewed by others
REFERENCES
L.V. Adamyan and V. I. Kulakov, Endometriosis [in Russian], Moscow (1998).
Yu. S. Antsiferova, N. Yu. Sotnikova, L. V. Poiseeva, and A. L. Shor, Akush. Ginekol., No. 5, 41–44 (2003).
N. I. Kondrikov and L. V. Adamyan, Ibid., No. 2, 9–12 (1999).
R. V. Pavlov, V. A. Aksenenko, and S. A. Sel’kov, Zh. Akush. Zhensk. Bol., No. 1, 74–77 (2002).
M. A. Pal’tsev and A. A. Ivanov, Cell-to-Cell Interactions [in Russian], Smolensk (1995).
A. V. Pomortsev, G. V. Gudkov, and A. M. Degtyarev, Akush. Ginekol., No. 4, 35–41 (2002).
S. A. Sel’kov, N. L. Kramareva, O. V. Pavlov, and M. I. Yarmolinskaya, Zh. Akush. Zhensk. Bol., 51, No.3, 57–62 (2002).
S. A. Sel’kov, M. I. Yarmolinskaya, V. V. Grigor’eva, et al., Vestn. Ros. Ass. Akush.-Ginek., No. 3, 40–43 (1997).
A. S. Simbirtsev, Tsitokiny i Vospalenie, 1, No.1, 9–17 (2002).
I. S. Freidlin and A. A. Totolyan, Immune System Cells [in Russian], Vol. 3–4, St. Petersburg (2001).
T. Cohen, D. Nahari, L. W. Cerem, et al., J. Biol. Chem., 271, 736–741 (1996).
S. M. Hyder and G. M. Stancel, Mol. Endocrinol., 13, No.6, 806–811 (1999).
M. Nissole, F. Casanas-Roux, V. Anaf, et al., Fertil. Steril., 59, 681–684 (1993).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 4, pp. 439–42, April, 2005
Rights and permissions
About this article
Cite this article
Sel’kov, S.A., Solodovnikova, N.G., Pavlov, O.V. et al. Local Production of Interleukins and Growth Factors in External Genital Endometriosis. Bull Exp Biol Med 139, 444–447 (2005). https://doi.org/10.1007/s10517-005-0318-y
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0318-y