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Binding of LPS and LPS—LDL Complexes to Rat Hepatocytes

  • Immunology and Microbiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We studied binding of 3H-LPS toxin and LPS complexes with serum 125I-LDL to primary culture of rat hepatocytes. Receptor binding of LPS and LDL—LPS complex was ∼50 and 77% of the total, respectively. Scatchard plot was linear in both cases. LDL and LDL—LPS complexes were inessential for LPS binding, while LDL—LPS binding was appreciably suppressed by LPS (−30%) and LDL (−65%).

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Authors and Affiliations

  1. Laboratory of Molecular Mechanisms of Infections, Central Institute of Epidemiology, Moscow, Russia

    A. V. Viktorov & V. A. Yurkiv

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  1. A. V. Viktorov
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  2. V. A. Yurkiv
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Correspondence to A. V. Viktorov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 4, pp. 436–438, April, 2005

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Viktorov, A.V., Yurkiv, V.A. Binding of LPS and LPS—LDL Complexes to Rat Hepatocytes. Bull Exp Biol Med 139, 441–443 (2005). https://doi.org/10.1007/s10517-005-0317-z

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  • DOI: https://doi.org/10.1007/s10517-005-0317-z

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