Abstract
We studied the association of GSTM1 and GSTT1 and GSTP1 Ile105-Val105 polymorphism with the duration of intoxication, polyorgan failure, and severity of drug poisoning in children. The combination of GSTM1 and GSTT1 zero genotypes is a favorable sign for the duration of intoxication and severity of the disease.
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REFERENCES
A. L. Levit, A. V. Rudnov, A. A. Belkin, et al., Vestn. Intens. Ter., No. 4, 3–11 (2003).
I. N. Pasechnik, Ibid., No. 4, 3–9 (2001).
Casarett and Doulls Toxicology: The Basic Science of Poisons, Ed. C. D. Klaassen, New York (2001).
S. Dorion, H. Lambert, and J. Landry, J. Biol. Chem., 277, No.34, 30,792–30,797 (2002).
L. W. Harries, M. J. Stubbins, D. Forman, et al., Carcinogenesis, 18, No.4, 641–644 (1997).
S. I. James and J. T. Ahokas, Xenobiotica, 22, No.12, 1433–1439 (1992).
S. Pemble, K. R. Schroeder, S. R. Spencer, et al., Biochem. J., 300, Pt. 1, 271–276 (1994).
K. Sano, Y. Totsuka, Y. Ikegami, and T. Uesugi, J. Pharm. Pharmacol., 54, No.2, 231–239 (2002).
T. Wang, P. Arifoglu, Z. Ronai, and K. D. Tew, J. Biol. Chem., 276, No.24, 20,999–21,003 (2001).
M. H. Wilson, P. J. Grant, L. J. Hardie, and C. P. Wild, FASEB J., 14, No.5, 791–796 (2000).
S. Zhong, A. H. Wyllie, D. Barnes, et al., Carcinogenesis, 14, No.9, 1821–1824 (1993).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 4, pp. 424–427, April, 2005
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Vavilin, V.A., Safronova, O.G., Manankin, N.A. et al. Glutathione-S-Transferase Polymorphism and Clinical Features of Acute Drug Poisoning in Children. Bull Exp Biol Med 139, 431–433 (2005). https://doi.org/10.1007/s10517-005-0314-2
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DOI: https://doi.org/10.1007/s10517-005-0314-2