Abstract
The effects of 5-HT3 receptor antagonists tropisetron and condensed derivative of benzimidazole (laboratory code 64B) on nociceptive threshold were examined on models with activation of peripheral and central nociceptive mechanisms. The examined substances demonstrated pronounced analgesic effects in peripheral pain.
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REFERENCES
M. V. Chernikov, A. A. Spasov, V. A. Anisimova, Arkh. Klin. Eksp. Med., 11, No.1, 29–33 (2002).
V. Babenko, T. Graven-Nielsen, P. Svensson et al., Pain, 82, No.1, 1–8 (1999).
P. K. Eide and K. Hole, Cephalalgia, 13, No.2, 75–85 (1993).
M. Ernberg, T. Lundeberg, and S. Kopp, Pain, 85, Nos.1–2, 31–39 (2000).
J. Giordano and L. V. Rogers, Eur. J. Pharmacol., 170, Nos.1–2, 83–86 (1989).
S. R. Glaum and E. G. Anderson, Ibid., 156, No.2, 287–290 (1988).
P. Hrycaj, T. Stratz, P. Mennet, and W. Muller, J. Rheumatol., 23, No.8, 1418–1423 (1996).
M. J. Iadarola, L. S. Brady, G. Draisci, and R. Dubner, Pain, 35, No.3, 313–326 (1988).
S. G. Khasabov, J. A. Lopez-Garcia, A. U. Asghar, and A. E. King, Br. J. Pharmacol., 127, No.4, 843–852 (1999).
D. Le Bars, M. Gozariu, and S. W. Cadden, Pharm. Rev., 53, No.4, 567–652 (2001).
Y. B. Peng, J. Wu, W. D. Willis, and D. R. Kenshalo, Neurophysiol., 86, No.1, 49–58 (2001).
K. P. Zeitz, N. Guy, A. B. Malmberg, et al., J. Neurosci., 3, No.22, 1010–1019 (2002).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 4, pp. 416–419, April, 2005
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Spasov, A.A., Chernikov, M.V. & Kiabiya, S.T. Analgesic Activity of 5-HT3 Receptor Antagonists. Bull Exp Biol Med 139, 424–426 (2005). https://doi.org/10.1007/s10517-005-0312-4
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DOI: https://doi.org/10.1007/s10517-005-0312-4