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Effect of Experimental Desynchronosis on Immunotoxicity of Benz(a)pyrene in (CBA×C57Bl)F1 Mice

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Abstract

Experiments on (CBA×C57Bl)F1 mice showed that constant (day and night) illumination for 2 weeks led to the development of internal desynchronosis, which significantly modulated the reaction of the immune system to benz(a)pyrene compared to those in intact animals. Presumably, the differences were associated with changed circadian rhythms of the immune parameters in experimental animals determining different ratios and, presumably, functions of immunocompetent cells during benz(a)pyrene exposure in intact controls and animals with desynchronosis.

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Authors and Affiliations

  1. Institute of Clinical and Experimental Lymphology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk, Russia

    A. V. Shurlygina, S. V. Michurina, L. V. Verbitskaya, E. V. Mel’nikova & V. A. Trufakin

  2. Central Research Laboratory, Novosibirsk State Medical Academy, Ministry of Health, Russian Federation

    A. V. Shurlygina, S. V. Michurina, L. V. Verbitskaya, E. V. Mel’nikova & V. A. Trufakin

Authors
  1. A. V. Shurlygina
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  2. S. V. Michurina
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  3. L. V. Verbitskaya
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  4. E. V. Mel’nikova
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  5. V. A. Trufakin
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Correspondence to A. V. Shurlygina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 2, pp. 223–226, February, 2005

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Shurlygina, A.V., Michurina, S.V., Verbitskaya, L.V. et al. Effect of Experimental Desynchronosis on Immunotoxicity of Benz(a)pyrene in (CBA×C57Bl)F1 Mice. Bull Exp Biol Med 139, 252–255 (2005). https://doi.org/10.1007/s10517-005-0262-x

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  • DOI: https://doi.org/10.1007/s10517-005-0262-x

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