Abstract
The content of stromal precursor cells in heterotopic splenic transplants from old and young mice changed appreciably after cross transplantation to old and young animals. The content of CFC-F in the young→old transplants decreased almost 1.5 times in comparison with the young→young transplants, the counts of CFC-F in old→old transplants were minimum in comparison with all other groups (2.5±0.1), while in the old→ young group transplants this value increased almost 8-fold (to 19.0±1.3) and surpassed the control level. Age-associated shifts in the splenic stromal tissue were determined by regulatory influences of the host, rather than by decreased count of stromal precursor cells in the tissue.
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REFERENCES
Yu. F. Gorskaya, A. I. Kuralesova, E. Yu. Shuklina, and V. G. Nesterenko, Byull. Eksp. Biol. Med., 133, No.2, 176–178 (2002).
Yu. F. Gorskaya, A. Ya. Fridenshtein, N. V. Latsinik, et al., Ibid., 127, No.2, 218–220 (1999).
A. Ya. Fridenshtein, Yu. F. Gorskaya, N. V. Latsinik, et al., Ibid., 128, No.5, 550–553.
A. Ya. Fridenshtein and E. A. Luriya, Cell Basis of Hemopoietic Microenvironment [in Russian], Moscow (1980).
R. K. Chailakhyan, N. V. Latsinik, P. A. Ivanov, et al., Cellular Molecular Aspects of Tissue Regeneration and Reconstruction [in Russian], Moscow (1998), pp. 34–35.
R. J. Bergman, D. Gazit, A. J. Kahn, et al., J. Bone Miner. Res., 11, 568–577 (1996).
E. L. Herzog, L. Chai, and D. S. Krause, Blood, 102, 3483–3493 (2003).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 2, pp. 196–198, February, 2005
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Gorskaya, Y.F., Nesterenko, V.G. Counts of Stromal Precursor Cells in Heterotopic Splenic Transplants in CBA Mice of Different Age. Bull Exp Biol Med 139, 227–229 (2005). https://doi.org/10.1007/s10517-005-0255-9
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DOI: https://doi.org/10.1007/s10517-005-0255-9