Abstract
The fate of human fetal stem/progenitor cells transplanted into rat brain depends on conditions of preculturing (long or short) and state and site of transplantation. Human nestin-positive stem cells cultured according to the short protocol did not migrate into hypoxic and normal brain after transplantation, but actively migrated in damaged spinal cord. After transplantation of long-cultured cells into the brain mainly committed neuroblasts and solitary nestin-positive cells migrated from the site of transplantation into the brain.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 2, pp. 181–184, February, 2005
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Revishchin, A.V., Aleksandrova, M.A., Podgornyi, O.V. et al. Human Fetal Neural Stem Cells in Rat Brain: Effects of Preculturing and Transplantation. Bull Exp Biol Med 139, 213–216 (2005). https://doi.org/10.1007/s10517-005-0251-0
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DOI: https://doi.org/10.1007/s10517-005-0251-0