Abstract
Preliminary selective block of μ-, δ1-, δ2-, and κ-opioid receptors had no effect on the incidence of ventricular arrhythmias during 10-min coronary occlusion-reperfusion in ketamine-narcotized rats. Repetitive short-term immobilization of rats for 2 weeks improved heart resistance to the arrhythmogenic action of coronary occlusion and reperfusion. Selective μ-opioid receptor antagonist CTAP completely abolished, while selective δ- and κ-opioid receptor antagonists did not modulate the antiarrhythmic effect of adaptation. Probably, endogenous agonists of μ-opioid receptors play an important role in the adaptive improvement of heart resistance to arrhythmogenic factors, but are insignificant for the modulation of heart resistance to the arrhythmogenic action of short-term local ischemia-reperfusion in non-adapted animals.
Similar content being viewed by others
REFERENCES
Yu. B. Lishmanov and L. N. Maslov, Kardiologiya, No. 3, 51–57 (2002).
Yu. B. Lishmanov and L. N. Maslov, Patol. Fiziol. Eksp. Ter., No. 1, 2–10 (2003).
L. N. Maslov, Yu. B. Lishmanov, and G. N. Smagin, Eksp. Klin. Farmakol., 65, No.2, 70–75 (2002).
J. L. Bergey and M. E. Beil, Eur. J. Pharmacol., 90, 427–431 (1983).
P. J. Birch, A. G. Hayes, M. J. Sheehan, and M. B. Tyers, Ibid., 144, 405–408 (1987).
R. W. Caldwell, R. Nagarajan, A. Chryssanthis, and R. R. Tuttle, Pharmacology, 41, 161–166 (1990).
O. Fagbemi, I. Lepran, and J. R. Parratt, Br. J. Pharmacol., 76, 504–506 (1982).
R. M. Fryer, A. K. Hsu, H. Nagase, and G. J. Gross, J. Pharmacol. Exp. Ther., 294, No.2, 451–457 (2000).
P. Y Law and H. H. Loh, Ibid., 289, No.2, 607–624 (1999).
L. N. Maslov, Y. B. Lishmanov, N. V. Solenkova, et al., Life Sci., 73, No.7, 947–952 (2003).
F. Z. Meerson and I. Yu. Malyshev, J. Mol. Cell. Cardiol., 21, 299–303 (1983).
R. J. Milne, J. M. Coddington, and G. F. Gamble, Neurosci. Lett., 11, 259–264 (1990).
D. C. Russell, J. S. Lawrie, R. A. Riemersma, and M. F. Oliver, Am. J. Cardiol., 53, 307–312 (1984).
Y. Sarne, A. Flitstein, and E. Oppenheimer, Br. J. Pharmacol., 102, 696–698 (1991).
M. Sofuoglu, P. S. Portoghese, and A. E. Takemori, Life Sci., 52, No.8, 769–775 (1993).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 2, pp. 138–142, February, 2005
Rights and permissions
About this article
Cite this article
Maslov, L.N., Lishmanov, Y.B., Naryzhnaya, N.V. et al. Role of Endogenous Opioid Receptor Agonists in Regulation of Heart Resistence to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion. Bull Exp Biol Med 139, 172–175 (2005). https://doi.org/10.1007/s10517-005-0239-9
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0239-9