Abstract
Study of MDR1 polymorphism in intron 6 and exon 12 of healthy individuals and patients with chronic lymphoproliferative diseases showed that the presence of mutant 6+139T allele is a factor determining resistance to lymphoproliferative diseases. Comparison of genotyping results in 53 patients and the data on the efficiency of drug therapy showed no significant associations of C1236T and C6+139T genotypes with drug resistance.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 454–457, October, 2004
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Goreva, O.B., Grishanova, A.Y., Domnikova, N.P. et al. MDR1 gene C1236T and C6+139T polymorphisms in the Russian population: Associations with predisposition to lymphoproliferative diseases and drug resistance. Bull Exp Biol Med 138, 404–406 (2004). https://doi.org/10.1007/s10517-005-0112-x
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DOI: https://doi.org/10.1007/s10517-005-0112-x