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Activating effect of Tanacetum vulgare L. pectin polysaccharide on ionic channels of neuronal membrane

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Abstract

The membranotropic effects of TVF tanacetan pectin polysaccharide derived from Tanacetum vulgare L. was studied by the voltage-clamp method on isolated neurons of Lymnaea stagnalis mollusk. TVF in concentrations of 0.1–10.0 µg/ml nonselectively activated the outward potassium and total inward (sodium and calcium) ionic currents (slightly dose-dependently and reversibly increased their amplitude by 5–10%) and decreased nonspecific leakage current.

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Authors and Affiliations

  1. Institute of Physiology, Komi Research Center, Ural Division of Russian Academy of Sciences, Syktyvkar

    V. I. Prosheva & A. Ya. Polle

  2. Institute of Pharmacology, I. P. Pavlov State Medical University, St. Petersburg

    A. I. Vislobokov

Authors
  1. A. I. Vislobokov
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  2. V. I. Prosheva
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  3. A. Ya. Polle
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Corresponding author

Correspondence to V. I. Prosheva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 439–441, October, 2004

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Vislobokov, A.I., Prosheva, V.I. & Polle, A.Y. Activating effect of Tanacetum vulgare L. pectin polysaccharide on ionic channels of neuronal membrane. Bull Exp Biol Med 138, 390–392 (2004). https://doi.org/10.1007/s10517-005-0108-6

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  • DOI: https://doi.org/10.1007/s10517-005-0108-6

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