Abstract
Perfusion of the isolated intact rat heart with Krebs—Henseleit solution containing agonists ((-)-TAN-67, DPDPE, and dalargin) or antagonists of δ-opioid receptors (naltrindole, TIPP[ψ], and ICI 174,864) in a final concentration of 0.1 mg/liter was followed by a decrease in the heart rate, end-diastolic pressure, contraction rate, relaxation rate, and left ventricular developed pressure. Perfusion with a solution containing the δ-opioid receptor agonist DPDPE or δ-antagonists naltrindole, TIPP[ψ], and ICI 174,864 before modeling of global ischemia increased the severity of reperfusion-induced contractile dysfunction in the myocardium. Our results suggest that δ-opioid receptor antagonists in vitro exhibit properties of partial δ-receptor agonists.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 424–427, October, 2004
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Maslov, L.N., Lasukova, T.V., Bespalova, Z.D. et al. δ-opioid receptor antagonists exhibit properties of partial δ-receptor agonists in isolated perfused heart. Bull Exp Biol Med 138, 376–379 (2004). https://doi.org/10.1007/s10517-005-0104-x
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DOI: https://doi.org/10.1007/s10517-005-0104-x