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Stimulation of immunotoxicity of chemicals metabolizing in vivo into highly toxic compounds by the monooxygenase system inductors

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Abstract

Oral treatment of experimental random-bred albino rats with inductors of the monooxygenase system phenobarbital (50 mg/kg) and benzenal (70 mg/kg) for 3 days until acute poisoning with toxins (methanol, ethylene glycol, and dichloroethane in doses of 1.0 LD50) metabolizing in the body to compounds with higher toxicity (phenomenon of lethal synthesis) increased immunotoxicity of these inductors.

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Authors and Affiliations

  1. Saratov Military Institute of Radiation, Chemical, and Biological Protection, Russia

    P. F. Zabrodskii, N. M. Troshkin & V. G. Mandych

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  1. P. F. Zabrodskii
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  2. N. M. Troshkin
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  3. V. G. Mandych
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 416–419, October, 2004 Original article submitted February 17, 2004

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Zabrodskii, P.F., Troshkin, N.M. & Mandych, V.G. Stimulation of immunotoxicity of chemicals metabolizing in vivo into highly toxic compounds by the monooxygenase system inductors. Bull Exp Biol Med 138, 369–371 (2004). https://doi.org/10.1007/s10517-005-0102-z

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  • DOI: https://doi.org/10.1007/s10517-005-0102-z

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