Abstract
We studied changes in the erythroid hemopoietic stem during phenylhydrazine-induced hemolytic anemia. Stimulation of erythropoiesis was associated with increased functional activity of erythroid precursors, which resulted from changes in feeder capacity of hemopoiesis-inducing microenvironmental cells and erythropoietic activity of the plasma. The development of encephalopathy induced by a hemolytic poison was accompanied by a decrease in hyperplasia of bone marrow erythropoiesis. It was related to a decrease in the number of proliferating erythroid precursor cells. These changes accompanied the increase in the secretory function of adherent myelokaryocytes, rise in erythropoietic activity of the plasma, enhanced formation of erythroid hemopoietic islets, and accelerated maturation of hemopoietic cells.
This is a preview of subscription content, log in via an institution to check access.
REFERENCES
Ya. Buresh, O. Bureshova, G. P. Houston, Methods and Main Experiments in Studies of the Brain and Behavior [in Russian], Ed. A. S. Batuev, Moscow (1991)
Hypoxia; Adaptation, Pathogenesis, and Clinics [in Russian], Ed. Yu. L. Shevchenko, St. Petersburg (2000).
E. D. Gol’dberg, A. M. Dygai, and G. N. Zyuz’kov, Eksperimental’na Klinichna Meditsina, No. 2, 30–35 (2003).
E. D. Gol’dberg, A. M. Dygai, G. N. Zyuz’kov, et al., Byull. Eksp. Biol. Med., 134, No. 8, 142–145 (2002).
E. D. Gol’berg, A. M. Dygai, and V. P. Shakhov, Tissue Culture Methods in Hematology [in Russian], Tomsk (1992).
Yu. M. Zakharov and A. G. Rassokhin, Erythroblastic Islet [in Russian], Moscow (2002).
G. N. Zyuz’kov, L. A. Gur’yantseva, N. I. Suslov, et al., Byull. Eksp. Biol. Med., 134, No. 10, 379–382 (2002).
Manual on Laboratory Studies in Clinical Practice [in Russian], Ed. V. V. Men’shikov, Moscow (1987).
Toxicology, Hygiene, and Occupational Diseases [in Russian], Ed. S. D. Zaugol’nikov, Moscow (1982), pp. 260–263.
Y. Fujii, N. Terada, H. Ueda, et al., J. Electron Microsc. (Tokyo), 46, No. 6, 477–484 (1997).
M. F. McMullin, T. R. Lappin, G. E. Elder, et al., Biochem. Med. Metab. Biol., 41, No. 1, 30–36 (1989).
P. A. Redondo, A. I. Alvarez, C. Diez, et al., Lab. Anim. Sci., 45, No. 5, 578–583 (1995).
R. N. Walsh and R. A. Cummins, Psychol. Bull., 83, 482–504 (1976).
Author information
Authors and Affiliations
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 378–381, October, 2004
Rights and permissions
About this article
Cite this article
Zyuz’kov, G.N., Abramova, E.V., Dygai, A.M. et al. Mechanisms of regulation of erythropoiesis during hemolytic anemia. Bull Exp Biol Med 138, 334–337 (2004). https://doi.org/10.1007/s10517-005-0092-x
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0092-x