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Effect of MK-801 on sensitivity of the respiratory system to oxygen deficiency and organism’s resistance to hypoxia

  • General Pathology and Pathological Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We studied changes in organism’s sensitivity and resistance to hypoxic hypoxia under conditions of NMDA receptor blockade with MK-801. Breathing hypoxic gas mixture after administration of MK-801 sharply decreased the mean blood pressure in the systemic circulation and slightly improved lung ventilation in animals. Respiratory arrest was observed in 40% animals. NMDA receptor blockade decreased organism’s sensitivity and resistance to hypoxic hypoxia.

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Authors and Affiliations

  1. Laboratory for Pathophysiology of Respiration, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    I. A. Tarakanov, A. Dymetska & N. N. Tarasova

  2. Department of Neurophysiology, Medical Research Center, Poland Academy of Sciences, Warsaw

    I. A. Tarakanov, A. Dymetska & N. N. Tarasova

Authors
  1. I. A. Tarakanov
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  2. A. Dymetska
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  3. N. N. Tarasova
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Correspondence to I. A. Tarakanov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 373–377, October, 2004

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Tarakanov, I.A., Dymetska, A. & Tarasova, N.N. Effect of MK-801 on sensitivity of the respiratory system to oxygen deficiency and organism’s resistance to hypoxia. Bull Exp Biol Med 138, 330–333 (2004). https://doi.org/10.1007/s10517-005-0091-y

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  • DOI: https://doi.org/10.1007/s10517-005-0091-y

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