Abstract
Experiments were performed with 62 longitudinal strips of the uterine horns from 10 nonpregnant rats. The ability of continuously infused epinephrine in high concentration (10−6 g/ml, 30 min) to suppress spontaneous contractions due to activation of β-adrenoceptors progressively decreased, which was associated with receptor desensitization. Histidine in a concentration of 3×10−11 g/ml had no effect, while in concentrations of 3×10−8, 3×10−7, and 3×10−6 g/ml decreased the degree of desensitization. Our results indicate that histidine not only potentiates β-adrenoceptor activation, but also prevents the development of desensitization. These data should be taken into account during therapy with β-adrenoceptor agonists.
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REFERENCES
A. E. Avakyan and V. A. Tkachuk, Ros. Fiziol. Zh., 89, No. 2, 219–239 (2003).
I. G. Vlasova and V. I. Tsirkin, Chronostructure and Chronoecology of Reproductive Function [in Russian], Moscow (2000), pp. 49–51.
A. D. Nozdrachev, T. V. Tumanova, S. A. Dvoryanskii, et al., Dokl. Ros. Akad. Nauk, 363, No. 1, 133–136 (1998).
P. V. Sergeev, N. L. Shimanovskii, and V. I. Petrov, Receptors for Physiologically Active Substances [in Russian], Volgograd (1999).
E. N. Sizova, V. I. Tsirkin, A. A. Kostyaev, et al., Vyatskii Med. Vestn., No. 1, 49–53 (2003).
A. N. Trukhin, V. I. Tsirkin, and E. N. Sizova, Ibid., No. 3, 58–67 (2003).
V. I. Tsirkin and S. A. Dvoryanskii, Contractile Activity of the Uterus (Mechanisms for Regulation) [in Russian], Kirov (1997).
V. I. Tsirkin, S. A. Dvoryanskii, A. D. Nozdrachev, et al., Dokl. Ros. Akad. Nauk, 352, No. 1, 124–126 (1997).
H. Abe, Neirokhimiya, No. 4, 279–287 (1996).
O. Cantoni and P. Giacomoni, Gen. Pharmacol., 28, No. 4, 513–516 (1997).
J. Krupnick and J. Benovic, Ann. Rev. Pharmacol. Toxicol., 38, No. 2, 289–319 (1998).
R. Lefkowitz, J. Biol. Chem., 272, 18,677–18,680 (1998).
Li Shu-Qing, Zhao Gang, Li Jun, and Qian Wei, Zhongguo Yaoli Xuebao, 19, No. 5, 493–496 (1998).
H. Mizukawa and E. Okabe, Br. J. Pharmacol., 120, No. 1, 63–70 (1997).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 364–367, October, 2004
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Tumanova, T.V., Sizova, E.N. & Tsirkin, V.I. Ability of L-histidine to decrease desensitization of the myometrium to epinephrine. Bull Exp Biol Med 138, 321–324 (2004). https://doi.org/10.1007/s10517-005-0089-5
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DOI: https://doi.org/10.1007/s10517-005-0089-5