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Chronic administration of imipramine decreases freezing time in rats genetically predisposed to catalepsy

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Abstract

The effects of acute and chronic imipramine treatment on the degree of catalepsy were compared in GC rats genetically predisposed to catalepsy. We recorded the time over which the rats remained in a vertical position they were placed. As differentiated from acute treatment, chronic administration of imipramine dose-dependently decreased the time of freezing in GC rats.

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Authors and Affiliations

  1. Laboratory for Neurogenomics of Behavior, Russia

    A. V. Kulikov, M. A. Tikhonova, V. F. Chugui, T. A. Alekhina, V. G. Kolpakov & N. K. Popova

  2. Laboratory of Evolutionary Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.

    V. F. Chugui, T. A. Alekhina & V. G. Kolpakov

Authors
  1. A. V. Kulikov
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  2. M. A. Tikhonova
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  3. V. F. Chugui
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  4. T. A. Alekhina
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  5. V. G. Kolpakov
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  6. N. K. Popova
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Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 450–453, October, 2004

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Kulikov, A.V., Tikhonova, M.A., Chugui, V.F. et al. Chronic administration of imipramine decreases freezing time in rats genetically predisposed to catalepsy. Bull Exp Biol Med 138, 401–403 (2004). https://doi.org/10.1007/s10517-005-0053-4

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  • DOI: https://doi.org/10.1007/s10517-005-0053-4

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