Abstract
The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipoproteins. Polyethylene glycol-induced association of low-density lipoproteins was irreversible. Our results suggest that atherogenic activity of circulating modified low-density lipoproteins is associated with their increased predisposition to irreversible association.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
A. N. Klimov and N. G. Nikul’cheva, Lipids, Lipoproteins, and Atherosclerosis [in Russian], St Petersburg (1995).
K. Arnold, J. Arnhold, O. Zschornig, et al., Biomed. Biochim. Acta, 48, 735–742 (1989).
K. Arnold, A. Herrmann, K. Gawrisch, and L. Pratsch, Molecular Mechanisms of Membrane Fusion, New York (1987), pp. 118–137.
K. Arnold and O. Zschornig, Biomed. Biochim. Acta, 47, 949–954 (1988).
M. A. Austin, J. L. Breslow, C. H. Hennekens, et al., JAMA, 260, 1917–1921 (1988).
P. Avogaro, G. Bittolo Bon, and G. Cazzolato, Arteriosclerosis, 8, 79–87 (1988).
L. J. Hazell, J. J. M. van den Berg, and R. Stocker, Biochem. J., 302, 297–304 (1994).
H. F. Hoff, T. E. Whitaker, and J. O’Neil, J. Biol. Chem., 267, 602–609 (1992).
S. Ohki and K. Arnold, J. Membr. Biol., 114, 195–203 (1990).
A. N. Orekhov, V. V. Tertov, and D. N. Mukhin, Atherosclerosis, 86, 153–161 (1991).
V. V. Tertov, V. V. Kaplun, and A. N. Orekhov, Ibid., 138, 183–195 (1998).
V. V. Tertov, A. N. Orekhov, I. A. Sobenin, et al., Circulat. Res., 71, 218–228 (1992).
V. V. Tertov, I. A. Sobenin, Z. A. Gabbazov, et al., Biochem. Biophys. Res. Commun., 163, 489–494 (1989).
V. V. Tertov, I. A. Sobenin, Z. A. Gabbazov, et al., Lab. Invest., 67, 665–675 (1992).
V. V. Tertov, I. A. Sobenin, A. G. Tonevitsky, et al., Biochem. Biophys. Res. Commun., 167, 1122–1127 (1990).
Author information
Authors and Affiliations
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 428–431, October, 2004
Rights and permissions
About this article
Cite this article
Suprun, I.V., Mel’nichenko, A.A., Sobenin, I.A. et al. Resistance of native and circulating modified low-density lipoproteins in human blood to association. Bull Exp Biol Med 138, 380–383 (2004). https://doi.org/10.1007/s10517-005-0047-2
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0047-2