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Effect of in vivo hypoxic preconditioning on changes in intracellular calcium content induced by long-term anoxia in rat brain slices

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Abstract

We studied changes in intracellular calcium content induced by 10-min anoxia in olfactory cortex slices from rats exposed to single or 3-fold moderate hypobaric hypoxia (“ascend” at 5000 m). Repeated preconditioning with moderate hypobaric hypoxia produced a neuroprotective effect. This treatment abolished pathological calcium overload in brain slices induced in vitro by 10-min test anoxia.

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

    D. G. Semenov, O. L. Miller & M. O. Samoilov

Authors
  1. D. G. Semenov
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  2. O. L. Miller
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  3. M. O. Samoilov
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 382–384, October, 2004

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Semenov, D.G., Miller, O.L. & Samoilov, M.O. Effect of in vivo hypoxic preconditioning on changes in intracellular calcium content induced by long-term anoxia in rat brain slices. Bull Exp Biol Med 138, 338–340 (2004). https://doi.org/10.1007/s10517-005-0035-6

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  • DOI: https://doi.org/10.1007/s10517-005-0035-6

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