Abstract
Regeneration of the splenic tissue after partial splenectomy is incomplete in adult non-irradiated mice and lethally irradiated animals reconstituted with donor syngeneic bone marrow. Transplantation of the splenic tissue to intact adult animals after partial splenectomy resulted in virtually complete regeneration of the spleen. In chimeras recovery of the splenic tissue was decreased; autotransplantation of the whole spleen or its part did not lead to appreciable changes in the weight and cellularity of this organ. No more than 30% splenic tissue is restored after complete splenectomy and transplantation of the splenic tissue in intact and chimeric mice.
Similar content being viewed by others
REFERENCES
Y. Kluger M. Rabau R. Rub et al. (1999) J. Trauma 47 IssueID2 261–264 Occurrence Handle10452459 Occurrence Handle1:STN:280:DyaK1MznvFGhug%3D%3D Occurrence Handle10.1097/00005373-199908000-00007
D. Metcalf (1963) Aust. J. Exp. Biol. Med. 41 51–60 Occurrence Handle1:STN:280:DyaF387is1ygsA%3D%3D
D. Metcalf (1964) Transplantation 84 387–392 Occurrence Handle10.1097/00007890-196405000-00008
D. Metcalf and M. A. S. Moore, Hematopoietic Cells, Amsterdam, London (1971).
R. Pabst (1999) Clin. Exp. Immunol. 117 423–424 Occurrence Handle10469041 Occurrence Handle1:STN:280:DyaK1MzpvV2qsA%3D%3D
R. Pabst J. Westermann H. J. Rothkotter (1991) Int. Rev. Cytol. 28 215–260 Occurrence Handle10.1016/S0074-7696(08)60500-8
P. W. Pisters H. L. Pachter (1994) Ann. Surg. 219 225–235 Occurrence Handle8147604 Occurrence Handle1:STN:280:DyaK2c7pslCgsg%3D%3D
B. Ravo P. Trentino F. Cortesi et al. (1991) G. Chir. 12 IssueID3 155–159 Occurrence Handle1873155 Occurrence Handle1:STN:280:DyaK3MzjslKntg%3D%3D
W. H. Tang F. L. Wu M. K. Huang H. Friess (2003) Langenbecks Arch. Surg. 387 379–385 Occurrence Handle12536334
J. Westermann R. Pabst (1997) Cell Tissue Res. 287 357–364 Occurrence Handle8995207 Occurrence Handle1:STN:280:DyaK2s7lt1eqtQ%3D%3D
J. Westermann K. U. Willfuhr R. Pabst (1988) J. Pediatr. Surg. 23 835–838 Occurrence Handle3263490 Occurrence Handle1:STN:280:DyaL1M%2Fjs1Kgug%3D%3D
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 9, pp. 348–350, September, 2004
Rights and permissions
About this article
Cite this article
Nifontova, I.N., Drize, N.I. & Chertkov, I.L. Regeneration of the spleen in intact animals and radiation chimeras. Bull Exp Biol Med 138, 308–310 (2004). https://doi.org/10.1007/s10517-005-0028-5
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0028-5