Abstract
We compared the effects of Tamerit, Polyoxidony, and Licopid on spontaneous and lipopolysaccharide-stimulated production of interleukin-1 and tumor necrosis factor by mouse peritoneal macrophages in vitro. The test preparations were equally potent in stimulating nonactivated cells. Licopid produced a costimulatory effect on macrophages primed with endotoxin. Tamerit in different doses suppressed cytokine production by cells. Polyoxidony in low doses activated, but in high doses suppressed this process.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 9, pp. 293–295, September, 2004
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Nikitin, A.A., Abidov, M.T., Kovalevskaya, E.O. et al. Search for potent modulators of cytokine production by macrophages. Bull Exp Biol Med 138, 259–261 (2004). https://doi.org/10.1007/s10517-005-0015-x
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DOI: https://doi.org/10.1007/s10517-005-0015-x