Bulletin of Experimental Biology and Medicine

, Volume 138, Issue 3, pp 248–250 | Cite as

Low ionic strength promotes association of circulating modified LDL human blood

  • O. M. PanasenkoEmail author
  • I. V. Suprun
  • A. A. Mel’nichenko
  • I. A. Sobenin
  • A. N. Orekhov


The resistance to association of circulating multiply-modified low-density lipoproteins (LDL) isolated from human blood and characterized by a decreased content of sialic acids in comparison with native LDL was studied by analysing light transmission fluctuations. LDL association was stimulated by decreasing environmental ionic strength. It is established that circulating modified LDL are less resistant to association than native LDL. Association of LDL in a medium with low ionic strength was irreversible. Probably, increased capacity to irreversible association determines the atherogenic properties of circulating modified LDL subfraction.

Key Words

LDL modified LDL lipoprotein association lipoprotein aggregation atherosclerosis 


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  1. 1.
    H. Sontag and K. Strenge, Coagulation and Stability of Disperse Systems [in Russian], Leningrad (1973).Google Scholar
  2. 2.
    A. N. Klimov and N. G. Nikul’cheva, Lipids, Lipoproteins, and Atherosclerosis [in Russian], St. Petersburg (1995).Google Scholar
  3. 3.
    Tertov, V. V. 1999Angiol. Sosud. Khir.5218240Google Scholar
  4. 4.
    Austin, M. A., Breslow, J. L., Hennekens, C. H.,  et al. 1988JAMA26019171921Google Scholar
  5. 5.
    Avogaro, P., Bon, G. B., Cazzolato, G. 1988Arteriosclerosis87987Google Scholar
  6. 6.
    Goldstein, J. L., Brown, M. S. 1977Annu. Rev. Biochem.46897930Google Scholar
  7. 7.
    Hazell, L. J., Berg, J. J. M., Stocker, R. 1994Biochem. J.302297304Google Scholar
  8. 8.
    Hoff, H. F., Whitaker, T. E., O’Neil, J. 1992J. Biol. Chem.267602609Google Scholar
  9. 9.
    Orekhov, A. A., Tertov, V. V., Mukhin, D. N. 1991Atherosclerosis86153161Google Scholar
  10. 10.
    Tertov, V. V., Kaplun, V. V., Orekhov, A. A.,  et al. 1998Atherosclerosis138183195Google Scholar
  11. 11.
    Tertov, V. V., Orekhov, A. A. 1997Exp. Mol. Pathol.64127145Google Scholar
  12. 12.
    Tertov, V. V., Orekhov, A. A., Sobenin, I. A.,  et al. 1992Circ. Res.71218228Google Scholar
  13. 13.
    Tertov, V. V., Sobenin, I. A., Gabbasov, Z. A.,  et al. 1992Lab. Invest.67665675Google Scholar
  14. 14.
    Tertov, V. V., Sobenin, I. A., Gabbasov, Z. A.,  et al. 1989Biochem. Biophys. Res. Commun.163489494Google Scholar
  15. 15.
    Tertov, V. V., Sobenin, I. A., Tonevitsky, A. G.,  et al. 1990Biochem. Biophys. Res. Commun.16711221127Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • O. M. Panasenko
    • 1
    • 2
    Email author
  • I. V. Suprun
    • 1
  • A. A. Mel’nichenko
    • 2
  • I. A. Sobenin
    • 1
    • 3
  • A. N. Orekhov
    • 3
    • 4
  1. 1.Laboratory of Atherogenic Mechanisms, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production ComplexMinistry of HealthMoscow
  2. 2.Laboratory of Physicochemical Research and Analysis Methods, Research Institute of Physicochemical MedicineMinistry of HealthMoscow
  3. 3.Laboratory of Intercellular Interactions, Institute of General Pathology and Pathological PhysiologyRussian Academy of Medical SciencesMoscow
  4. 4.Research Institute of AtherosclerosisRussian Academy of Natural SciencesMoscow

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