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Bulletin of Experimental Biology and Medicine

, Volume 138, Issue 3, pp 248–250 | Cite as

Low ionic strength promotes association of circulating modified LDL human blood

  • O. M. PanasenkoEmail author
  • I. V. Suprun
  • A. A. Mel’nichenko
  • I. A. Sobenin
  • A. N. Orekhov
Article

Abstract

The resistance to association of circulating multiply-modified low-density lipoproteins (LDL) isolated from human blood and characterized by a decreased content of sialic acids in comparison with native LDL was studied by analysing light transmission fluctuations. LDL association was stimulated by decreasing environmental ionic strength. It is established that circulating modified LDL are less resistant to association than native LDL. Association of LDL in a medium with low ionic strength was irreversible. Probably, increased capacity to irreversible association determines the atherogenic properties of circulating modified LDL subfraction.

Key Words

LDL modified LDL lipoprotein association lipoprotein aggregation atherosclerosis 

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Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • O. M. Panasenko
    • 1
    • 2
    Email author
  • I. V. Suprun
    • 1
  • A. A. Mel’nichenko
    • 2
  • I. A. Sobenin
    • 1
    • 3
  • A. N. Orekhov
    • 3
    • 4
  1. 1.Laboratory of Atherogenic Mechanisms, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production ComplexMinistry of HealthMoscow
  2. 2.Laboratory of Physicochemical Research and Analysis Methods, Research Institute of Physicochemical MedicineMinistry of HealthMoscow
  3. 3.Laboratory of Intercellular Interactions, Institute of General Pathology and Pathological PhysiologyRussian Academy of Medical SciencesMoscow
  4. 4.Research Institute of AtherosclerosisRussian Academy of Natural SciencesMoscow

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