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Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity

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Abstract

Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure.

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Authors and Affiliations

  1. Department of Pathophysiology, Course of Clinical Pathophysiology, Omsk State Medical Academy, Russia

    M. V. Kolbina, V. T. Dolgikh & V. I. Chesnokov

Authors
  1. M. V. Kolbina
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  2. V. T. Dolgikh
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  3. V. I. Chesnokov
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Correspondence to M. V. Kolbina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 9, pp. 254–256, September, 2004

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Kolbina, M.V., Dolgikh, V.T. & Chesnokov, V.I. Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity. Bull Exp Biol Med 138, 223–225 (2004). https://doi.org/10.1007/s10517-005-0004-0

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  • DOI: https://doi.org/10.1007/s10517-005-0004-0

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