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Atomic Energy

, Volume 121, Issue 3, pp 208–213 | Cite as

Possibility of Obtaining High-Activity 177Lu in the IR-8 Research Reactor

  • P. P. Boldyrev
  • V. A. Zagryadskii
  • D. Yu. Erak
  • A. V. Kurochkin
  • D. V. Markovskii
  • O. V. Mikhin
  • M. A. Proshin
  • N. V. Khmyzov
  • D. Yu. Chuvilin
  • Yu. A. Yashin
Article
  • 31 Downloads

The results of the production of the medical isotope 177Lu in the IR-8 research reactor are presented. The quantitative and qualitative characteristics of the desired radionuclide are determined. The radiochemical method of separating 177Lu from an irradiated target 176Yb by a combination of two electrochemical processes – cementation of ytterbium from acetate-chloride solution on sodium amalgam and electrolysis of an ytterbium solution in a single electrolytic cell – is proposed. The purification factor for removal of 176Yb from 177Lu was 105–106.

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References

  1. 1.
    G. E. Kodina and R. N. Krasikova, Methods for Obtaining Radiopharmaceutical Preparations and Radionuclide Generators for Nuclear Medicine, Izd. Dom MEI, Moscow (2014).Google Scholar
  2. 2.
    S. Banerjee, M. R. A. Pillai, and F. F. Knapp, “Leutetium therapeutic radiopharmaceuticals: linking chemistry, radiochemistry,” Chem. Rev., 115, 2934–2974 (2015).CrossRefGoogle Scholar
  3. 3.
    A. V. Novik, “Targeted therapy with lymphoproliferative diseases,” Prakt. Onkol., 11, No. 3, 131–142 (2010).Google Scholar
  4. 4.
    V. A. Tarasov, O. I. Andreev, E. G. Romanov, et al., “Production of no-carrier added lutetium-177 by irradiation of enriched ytterbium-176,” Current Radiopharmac., 8, No. 2, 95–106 (2015).CrossRefGoogle Scholar
  5. 5.
    S. Mirzadeh, L. F. Mausner, and M. A. Garland, Reactor-Produced Medical Radionuclides: Handbook of Nuclear Chemistry, A. Vértes, S. Nagy, Z. Klencsár, et al. (eds.), Springer Sci.+Business Media B.V. (2011), pp. 1857–1902.Google Scholar
  6. 6.
    E. P. Ryazantsev, V. A. Nasonov, P. M. Yegorenkov, et al., “The current status and prospects for IR-8 reactor at the National Research Center Kurchatov Institute,” in: Abstr. Int. Sci. Techn. Conf. on Research Reactors in the 21st Century, Moscow, June 20–23, 2006, p. 27.Google Scholar
  7. 7.
    V. A. Nasonov, N. I. Alekseev, D. Y. Erak, et al., Development of Computational and Experimental Methods for Determining the Parameters of Neutron Fields in the Reactor IR-8 at the Kurchatov Institute for Fundamental and Applied Research, Preprint IAE-6579/4 (2009).Google Scholar
  8. 8.
    German Standart, DIN 25 456, Determination of the Fast Neutron-Fluence with Iran Activation Detectors (1990), Pt 2.Google Scholar
  9. 9.
    Yu. F. Rodionov and Yu. A. Yashin, “Analysis of the radionuclide composition of bulk samples according to their γ-radiation spectrum,” Vopr. At. Nauki Tekhn. Ser. Yad. Yad.-Fiz. Issled., 2, 50–51 (1989).Google Scholar
  10. 10.
    Le Van So, N. Morcus, M. Zaw, et al., “Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation,” J. Radional. Nucl. Chem., 277, No. 3, 651–683 (2008).CrossRefGoogle Scholar
  11. 11.
    E. Horwitz, D. McAlister, A. Bond, et al., “A process for the separation of 177Lu from neutron irradiated 176Yb targets,” Appl. Radiat. Isot., 63, No. 1, 23–36 (2005).CrossRefGoogle Scholar
  12. 12.
    S. Marx, M. Harfensteller, K. Zhernosekov, and T. Nikula, Patent US2014294700A1, “Method of manufacturing no-carrier-added high-purity 177Lu compounds as well as no-carrier-added 177Lu compounds,” publ. Oct. 2, 2014.Google Scholar
  13. 13.
    I. Cieszykowska, M. Zoltowska, and M. Mielcarski, “Separation of ytterbium from 177Lu/Yb mixture by electrolytic reduction and amalgamation,” SOP Trans. Appl. Chem., 1, No. 2, 6–13 (2014).CrossRefGoogle Scholar
  14. 14.
    R. Chakravarty, T. Das, A. Dash, et al., “An electro-amalgamation approach to isolate no-carrier-added 177Lu from neutron irradiated Yb for biomedical applications,” Nucl. Med. Biol., 37, No. 7, 811–820 (2010).CrossRefGoogle Scholar
  15. 15.
    N. A. Lebedev, A. F. Novgorodov, R. Misiak, et al., “Radiochemical separation of no-carrier-added as produced via the process,” Appl. Radiat. Isot., 53, 421–425 (2000).CrossRefGoogle Scholar
  16. 16.
    H. McCoy, “Europium and ytterbium amalgams,” J. Amer. Chem. Soc., 63, No. 6, 1622–1624 (1941).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • P. P. Boldyrev
    • 1
  • V. A. Zagryadskii
    • 1
  • D. Yu. Erak
    • 1
  • A. V. Kurochkin
    • 1
  • D. V. Markovskii
    • 1
  • O. V. Mikhin
    • 1
  • M. A. Proshin
    • 1
  • N. V. Khmyzov
    • 1
  • D. Yu. Chuvilin
    • 1
  • Yu. A. Yashin
    • 1
  1. 1.National Research Center Kurchatov InstituteMoscowRussia

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