The characteristics of 7.5–80 MeV proton cyclotrons for the production of short-lived and generator radionuclides for positron-emission tomography are presented. A classification of cyclotrons by proton energy is given. Recommendations are made for choosing compact 7.5–12 MeV cyclotrons for producing short-lived 18F, 15O, 13N, and 11C and cyclotrons with proton energy tens of MeV for producing the generators 68Ge/68Ga and 82Sr/82Rb.
Similar content being viewed by others
References
P. Schmor, “Review of cyclotrons for the production of radioactive isotopes for medical and industrial applications,” Rev. Accl. Sci. Tech., 4, 103–116 (2011).
Cyclotron Produced Radionuclides: Principles and Practice, Techn. Rep. Ser. No. 465, IAEA, Vienna (2008).
Production of Long Lived Parent Radionuclides for Generators: 68 Ge, 82 Sr, 90 Sr and 188 W, Radioisot. and Radiopharmac. Ser, No. 2, IAEA, Vienna (2010).
D. Friesel and T. Antaya, “Medical cyclotrons,” Rev. Accl. Sci. Tech., 2, 133–156 (2009).
M. Jensen, “Particle accelerators for PET radionuclides,” Nucl. Med. Rev., 15, 9–12 (2012).
A. I. Papash and Yu. G. Alenitskii, “Commercial cyclotrons, Pt. 1, Commercial cyclotrons in the energy range 10–20 MeV for isotope production,” Fiz. Elemen. Chast. At. Yadra, No. 39(4), 1150–1214 (2008).
P. V. Bogdanov, M. F. Vorogushin, E. A. Lamzin, et al., “Development of the compact cyclotrons CC-18/9, CC-12, and MCC-30/15 for the production of medical radioisotopes,” Zh. Tekh. Fiz., No. 81(10), 68–83 (2011).
P. V. Bogdanov, P. Heikkinen, M. F. Vorogushin, et al., “Particularities of the development of the magnetic system of the MCC 30/15 cyclotron and formation of a field using turning shims,” Zh. Tekh. Fiz., No. 80(11), 105–110 (2010).
Cyclotron Produced Radionuclide: Physical Characteristics and Production Methods, Tech. Rep. Ser. 468, IAEA, Vienna (2009).
B. L. Zhuikov, “Production of medical radionuclides in Russia: status and future – a review,” Appl. Rad. Isot., 84, 48–56 (2014).
L.V. Kravchuk, “Development of nuclear-physical medicines at the Institute of Nuclear Research of the Russian Academy of Sciences,” Usp. Fiz. Nauk, No. 180(6), 665–670 (2010).
B. L. Zhuikov, “Isotope production at the Institute of Nuclear Research of the Russian Academy of Sciences: reality and prospects,” Usp. Fiz. Nauk, No. 181(9), 1004–1011 (2011).
V. Awasthi, J. Watson, and H. Gali, “A dose on demand biomarker generator for automated production of [(18)F]F and [(18)F]FDG,” Appl. Rad. Isot., 89, 167–175 (2014).
M. Schultz, D. Mueller, and R. Baum, “A new automated NaCl based robust method for routine production of gallium-68 labeled peptides,” Appl. Rad. Isot., 76, 46–54 (2013).
Author information
Authors and Affiliations
Additional information
Translated from Atomnaya Énergiya, Vol. 118, No. 6, pp. 324–328, June, 2015.
Rights and permissions
About this article
Cite this article
Pashentsev, V.N. Production of Radionuclides for Cyclotron Positron-Emission Tomography. At Energy 118, 405–409 (2015). https://doi.org/10.1007/s10512-015-0015-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10512-015-0015-5