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Is the Loss of Trpc2 Gene Function a Real Working Hypothesis for the Emergence of Same-Sex Sexual Behavior in Old World Primates?

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References

  • Bakker, J., de Mees, C., Douhard, Q., Balthazart, J., Gabant, P., Szpirer, J., & Szpirer, C. (2006). α-Fetoprotein protects the developing female mouse brain from masculinization and defeminisation by estrogens. Nature Neuroscience, 9, 220–226.

    Article  Google Scholar 

  • Balthazart, J. (2012). The biology of homosexuality. Oxford: Oxford University Press.

    Google Scholar 

  • Baum, M. J. (2009). Sexual differentiation of pheromone processing: Links to male-typical mating behaviour and partner preference. Hormones and Behavior, 55, 579–588.

    Article  Google Scholar 

  • Berghard, A., & Buck, L. B. (1996). Sensory transduction in vomeronasal neurons: evidence for Gαo, Gαi2, and adenylyl cyclase II as major component of a pheromone signaling cascade. Journal of Neuroscience, 16, 909–918.

    Article  Google Scholar 

  • Berghard, A., Buck, L. B., & Liman, E. R. (1996). Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Proceedings of the National Academy of Sciences USA, 93, 2365–2369.

    Article  Google Scholar 

  • Chamero, P., Katsoulidou, V., Hendrix, P., Bufe, B., Roberts, R., Matsunami, H., … Leinders-Zufall, T. (2011). G protein Gαo is essential for vomeronasal function and aggressive behavior in mice. Proceedings of the National Academy of Sciences USA, 108, 12898–12903.

    Article  Google Scholar 

  • Edwards, D. A., & Burge, K. G. (1971). Early androgen treatment and male and female sexual behaviour in mice. Hormones and Behavior, 2, 49–58.

    Article  Google Scholar 

  • Fabre-Nys, C., & Gelez, H. (2007). Sexual behavior in ewes and other domestic ruminants. Hormones and Behavior, 52, 18–25.

    Article  Google Scholar 

  • Ganna, A., Verweij, K. J. H., Nivard, M. G., Maier, R., Wedow, R., Busch, A. S., … Zietsch, B. P. (2019). Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior. Science, 365. https://doi.org/10.1126/science.aat7693.

  • Hansen, N. S., & Gammie, S. C. (2009). Trpc2 gene impacts on maternal aggression, accessory olfactory bulb anatomy and brain activity. Genes, Brain and Behavior, 8, 639–649.

    Article  Google Scholar 

  • Keller, M., Pierman, S., Douhard, Q., Baum, M. J., & Bakker, J. (2006). The vomeronasal organ is required for the expression of lordosis behaviour, but not sex discrimination in female mice. European Journal of Neuroscience, 23, 521–530.

    Article  Google Scholar 

  • Kim, S., Ma, L., Jensen, K. L., Kim, M. M., Bond, C. T., Adelman, J. P., & Yu, C. R. (2012). Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ. Nature Neuroscience, 15, 1236–1244.

    Article  Google Scholar 

  • Kim, S., Ma, L., & Yu, C. R. (2011). Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons. Nature Communications, 2, 365. https://doi.org/10.1038/ncomms1368.

    Article  PubMed  Google Scholar 

  • Kimchi, T., Xu, J., & Dulac, C. (2007). A functional circuit underlying male sexual behaviour in the female mouse brain. Nature, 448, 1009–1014.

    Article  Google Scholar 

  • Leypold, B. G., Yu, C. R., Leinders-Zufall, T., Kim, M. M., Zufall, F., & Axel, R. (2002). Altered sexual and social behaviors in trp2 mutant mice. Proceedings of the National Academy of Sciences USA, 99, 6376–6381.

    Article  Google Scholar 

  • Liman, E. R., & Innan, H. (2003). Relaxed selective pressure on an essential component of pheromone transduction in primate evolution. Proceedings of the National Academy of Sciences USA, 100, 3328–3332.

    Article  Google Scholar 

  • Manning, A., & McGill, T. E. (1974). Neonatal androgen and sexual behaviour in female house mice. Hormones and Behavior, 5, 19–31.

    Article  Google Scholar 

  • Martel, K. M., & Baum, M. J. (2009). Adult testosterone treatment but not surgical disruption of voméeronasal function augments male-typical sexual behaviour in female mice. Journal of Neuroscience, 29, 7658–7666.

    Article  Google Scholar 

  • McCarthy, M. M., & Arnold, P. (2011). Reframing sexual differentiation of the brain. Nature Neuroscience, 14, 677–683.

    Article  Google Scholar 

  • Norlin, E. M., Gussing, F., & Berghard, A. (2003). Vomeronasal phenotype and behavioral alterations in Gαi2 mutant mice. Current Biology, 13, 1214–1219.

    Article  Google Scholar 

  • Oboti, L., Perez-Gomez, A., Keller, M., Jacobi, E., Birnbaumer, L., Leinders-Zufall, T., … Chamero, P. (2014). A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gαo. BMC Biology, 12(31), 1–17. https://doi.org/10.1186/1741-7007-12-31.

    Article  Google Scholar 

  • Omura, M., & Mombaerts, P. (2014). Trpc2-expressing sensory neurons in the main olfactory epithelium of the mouse. Cell Reports, 8, 583–595.

    Article  Google Scholar 

  • Pfaff, D. (1970). Nature of sex hormone effects on rat sex behaviour: Specificity of effects and individual patterns of response. Journal of Comparative and Physiological Psychology, 3, 349–358.

    Article  Google Scholar 

  • Pfau, D., Jordan, C. L., & Breedlove, S. M. (2019). The de-scent of sexuality: Did loss of a pheromone signalling protein permit the evolution of same-sex sexual behaviour in primates? Archives of Sexual Behavior. https://doi.org/10.1007/s10508-018-1377-2.

    Article  PubMed  Google Scholar 

  • Phoenix, C. H., Goy, R. W., Gerall, A. A., & Young, W. C. (1959). Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology, 65, 369–382.

    Article  Google Scholar 

  • Södersten, P. (1972). Mounting behaviour in the female rat during estrous cycle, after ovariectomy, and after estrogen or testosterone administration. Hormones and Behavior, 3, 307–320.

    Article  Google Scholar 

  • Stowers, L., Holy, T. E., Meister, M., Dulac, C., & Koentges, G. (2002). Loss of sex discrimination and male–male aggression in mice deficient for TRP2. Science, 295, 1493–1500.

    Article  Google Scholar 

  • Takigami, S., Mori, Y., Tanioka, Y., & Ichikawa, M. (2004). Morphological evidence for two types of mammalian vomeronasal system. Chemical Senses, 29, 301–310.

    Article  Google Scholar 

  • Tarozzo, G., Cappello, P., De Andrea, M., Walters, E., Margolis, F. L., Oestreicher, B., & Fasolo, A. (1998). Prenatal differentiation of mouse vomeronasal neurons. European Journal of Neuroscience, 10, 392–396.

    Article  Google Scholar 

  • Trouillet, A. C., Keller, M., Weiss, J., Leinders-Zufall, T., Birnbaumer, L., Zufall, F., & Chamero, P. (2019). Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice. Proceedings of the National Academy of Sciences USA, 116, 5135–5143.

    Article  Google Scholar 

  • Wakabayashi, Y., Mori, Y., Ichikawa, M., Yazaki, K., & Hagino-Yamagishi, K. (2002). A putative-pheromone receptor gene is expressed in two distinct olfactory organs in goats. Chemical Senses, 27, 207–213.

    Article  Google Scholar 

  • Wakabayashi, Y., Ohkura, S., Okamura, H., Mori, Y., & Ichikawa, M. (2007). Expression of a vomeronasal receptor gene (V1R) and G protein α subunits in goat, Capra hircus, olfactory receptor neurons. Journal of Comparative Neurology, 503, 371–380.

    Article  Google Scholar 

  • Wu, M. V., Manoli, D. S., Fraser, E. J., Coats, J. K., Tooluhn, J., Honda, S., … Shah, N. M. (2009). Estrogen masculinizes neural pathways and sex-specific behaviors. Cell, 139, 61–72.

    Article  Google Scholar 

  • Yohe, L. R., Davies, K. T. J., Rossiter, S. J., & Davalos, L. M. (2019). Expressed vomeronasal type-1 receptors (V1rs) in bats uncover conserved sequences underlying social chemical signaling. Genome Biology & Evolution. https://doi.org/10.1093/gbe/evz179.

    Article  Google Scholar 

  • Zang, J., & Webb, D. M. (2003). Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. Proceedings of the National Academy of Sciences USA, 100, 8337–8341.

    Article  Google Scholar 

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Acknowledgements

MK and PC are, respectively, CNRS and INRAE research associates in the unit of Behavioural and Reproductive Physiology, UMR INRAE/CNRS/University of Tours in Nouzilly, France.

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Correspondence to Matthieu Keller.

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Keller, M., Chamero, P. Is the Loss of Trpc2 Gene Function a Real Working Hypothesis for the Emergence of Same-Sex Sexual Behavior in Old World Primates?. Arch Sex Behav 50, 2293–2297 (2021). https://doi.org/10.1007/s10508-020-01664-4

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