References
Amateau, S. K., & McCarthy, M. M. (2004). Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior. Nature Neuroscience, 7(6), 643–650.
Arnold, A. P., Reue, K., Eghbali, M., Vilain, E., Chen, X., Ghahramani, N., … Williams-Burris, S. M. (2016). The importance of having two X chromosomes. Philosophical Transactions of the Royal Society London B, 371(1688), 20150113. https://doi.org/10.1098/rstb.2015.0113.
Bakker, J., & Brock, O. (2010). Early oestrogens in shaping reproductive networks: Evidence for a potential organisational role of oestradiol in female brain development. Journal of Neuroendocrinology, 22(7), 728–735.
Bakker, J., Honda, S., Harada, N., & Balthazart, J. (2002). The aromatase knock-out mouse provides new evidence that estradiol is required during development in the female for the expression of sociosexual behaviors in adulthood. Journal of Neuroscience, 22(20), 9104–9112.
Bakker, J., Pierman, S., & Gonzalez-Martinez, D. (2010). Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones. Hormones and Behavior, 57(4–5), 390–395.
Balthazart, J., & Court, L. (2017). Human sexual orientation: The importance of evidentiary convergence [Commentary]. Archives of Sexual Behavior, 46(6), 1595–1600.
Baum, M. J. (2006). Mammalian animal models of psychosexual differentiation: When is ‘translation’ to the human situation possible? Hormones and Behavior, 50(4), 579–588.
Brock, O., Baum, M. J., & Bakker, J. (2011). The development of female sexual behavior requires prepubertal estradiol. Journal of Neuroscience, 31(15), 5574–5578.
Brock, O., Douhard, Q., Baum, M. J., & Bakker, J. (2010). Reduced prepubertal expression of progesterone receptor in the hypothalamus of female aromatase knockout mice. Endocrinology, 151(4), 1814–1821.
Byne, W., Tobet, S., Mattiace, L. A., Lasco, M. S., Kemether, E., Edgar, M. A., … Jones, L. B. (2001). The interstitial nuclei of the human anterior hypothalamus: An investigation of variation with sex, sexual orientation, and HIV status. Hormones and Behavior, 40(2), 86–92.
Desroziers, E., Brock, O., & Bakker, J. (2017). Potential contribution of progesterone receptors to the development of sexual behavior in male and female mice. Hormones and Behavior, 90, 31–38.
Dohler, K. D., Srivastava, S. S., Shryne, J. E., Jarzab, B., Sipos, A., & Gorski, R. A. (1984). Differentiation of the sexually dimorphic nucleus in the preoptic area of the rat brain is inhibited by postnatal treatment with an estrogen antagonist. Neuroendocrinology, 38(4), 297–301.
Forger, N. G. (2018). Past, present and future of epigenetics in brain sexual differentiation. Journal of Neuroendocrinology, 30(2). https://doi.org/10.1111/jne.12492.
Jones, M. E., Boon, W. C., Proietto, J., & Simpson, E. R. (2006). Of mice and men: The evolving phenotype of aromatase deficiency. Trends Endocrinology and Metabolism, 17(2), 55–64.
Lenz, K. M., & Nelson, L. H. (2018). Microglia and beyond: Innate immune cells as regulators of brain development and behavioral function. Frontiers in Immunology, 9, 698. https://doi.org/10.3389/fimmu.2018.00698.
Lenz, K. M., Nugent, B. M., Haliyur, R., & McCarthy, M. M. (2013). Microglia are essential to masculinization of brain and behavior. Journal of Neuroscience, 33, 2761–2772.
Lenz, K. M., Pickett, L. A., Wright, C. L., Davis, K. T., Joshi, A., & McCarthy, M. M. (2018). Mast cells in the developing brain determine adult sexual behavior. Journal of Neuroscience, 38(37), 8044–8059.
LeVay, S. (1991). A difference in hypothalamic structure between heterosexual and homosexual men. Science, 253(5023), 1034–1037.
Luoto, S., Krams, I., & Rantala, M. J. (2018). A life history approach to the female sexual orientation spectrum: Evolution, development, causal mechanisms, and health. Archives of Sexual Behavior. https://doi.org/10.1007/s10508-018-1261-0.
McCarthy, M. M. (2012). Sexual differentiation of brain and behavior. In G. Fink, D. W. Pfaff, & J. Levine (Eds.), Handbook of neuroendocrinology (pp. 393–413). Cambridge, MA: Academic Press.
Mohr, M. A., DonCarlos, L. L., & Sisk, C. L. (2017). Inhibiting production of new brain cells during puberty or adulthood blunts the hormonally induced surge of luteinizing hormone in female rats. eNeuro, 4(5), ENEURO.0133-17.2017.
Mohr, M. A., Garcia, F. L., DonCarlos, L. L., & Sisk, C. L. (2016). Neurons and glial cells are added to the female rat anteroventral periventricular nucleus during puberty. Endocrinology, 157(6), 2393–2402.
Nagamani, M., McDonough, P. G., Ellegood, J. O., & Mahesh, V. B. (1979). Maternal and amniotic fluid steroids throughout human pregnancy. American Journal of Obstetrics and Gynecology, 134(6), 674–680.
Ngun, T. C., Ghahramani, N., Sanchez, F. J., Bocklandt, S., & Vilain, E. (2011). The genetics of sex differences in brain and behavior. Frontiers in Neuroendocrinology, 32(2), 227–246.
Ngun, T. C., & Vilain, E. (2014). The biological basis of human sexual orientation: Is there a role for epigenetics? Advances in Genetics, 86, 167–184.
Paredes, R. G., & Baum, M. J. (1995). Altered sexual partner preference in male ferrets given excitotoxic lesions of the preoptic area/anterior hypothalamus. Journal of Neuroscience, 15(10), 6619–6630.
Paredes, R. G., Tzschentke, T., & Nakach, N. (1998). Lesions of the medial preoptic area/anterior hypothalamus (MPOA/AH) modify partner preference in male rats. Brain Research, 813(1), 1–8.
Reinisch, J. M., Mortensen, E. L., & Sanders, S. A. (2017). Prenatal exposure to progesterone affects sexual orientation in humans. Archives of Sexual Behavior, 46(5), 1239–1249.
Reyes, F. I., Boroditsky, R. S., Winter, J. S., & Faiman, C. (1974). Studies on human sexual development. II. Fetal and maternal serum gonadotropin and sex steroid concentrations. Journal of Clinical Endocrinology and Metabolism, 38(4), 612–617.
Roselli, C. E., Larkin, K., Resko, J. A., Stellflug, J. N., & Stormshak, F. (2004). The volume of a sexually dimorphic nucleus in the ovine medial preoptic area/anterior hypothalamus varies with sexual partner preference. Endocrinology, 145(2), 478–483.
Roselli, C. E., & Stormshak, F. (2009). The neurobiology of sexual partner preferences in rams. Hormones and Behavior, 55(5), 611–620.
Ross, J. L., Roeltgen, D., Feuillan, P., Kushner, H., & Cutler, G. B., Jr. (1998). Effects of estrogen on nonverbal processing speed and motor function in girls with Turner’s syndrome. Journal of Clinical Endocrinology and Metabolism, 83(9), 3198–3204.
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., … Korach, K. S. (1994). Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. New England Journal of Medicine, 331(16), 1056–1061.
Swaab, D. F. (2007). Sexual differentiation of the brain and behavior.”. Best Practice & Research Clinical Endocrinology & Metabolism, 21(3), 431–444.
Thion, M. S., Gihoux, F., & Garel, S. (2018). Microglia and early brain development: An intimate journey. Science, 362, 185–189.
Wagner, C. K. (2006). The many faces of progesterone: A role in adult and developing male brain. Frontiers in Neuroendocrinology, 27(3), 340–359.
Wallen, K. (2005). Hormonal influences on sexually differentiated behavior in nonhuman primates. Frontiers in Neuroendocrinology, 26(1), 7–26.
Werling, D. M., Parikshak, N. N., & Geschwind, D. H. (2016). Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nature Communications, 7, 10717. https://doi.org/10.1038/ncomms10717.
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JB and CAC are, respectively, research director and senior research associate of the F.R.S.-FNRS.
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Cornil, C.A., Bakker, J. Alternative Views on the Role of Sex Steroid Hormones on the Emergence of Phenotypic Diversity in Female Sexual Orientation. Arch Sex Behav 48, 1309–1313 (2019). https://doi.org/10.1007/s10508-018-1343-z
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DOI: https://doi.org/10.1007/s10508-018-1343-z