This prospective study tested whether sexual activity and emotional closeness during partnered sexual activity relate to cognitive decline (episodic memory performance) in older adulthood. In total, 6016 adults aged 50 and over (2672 men, 3344 women; M age = 66.0 ± 8.8 years) completed an episodic memory task and self-report questions related to health, sexual activity, and emotional closeness. Two years later, participants again completed the episodic memory task. After controlling for demographic and health-related lifestyle factors, more frequent sexual activity and greater emotional closeness during partnered sexual activity were associated with better memory performance. The association between sexual activity and memory performance was stronger among older participants in the sample. Memory performance worsened over 2 years, but change in memory performance was unrelated to sexual activity or emotional closeness during partnered sexual activity. These findings build on experimental research that has found sexual activity enhances episodic memory in non-human animals. Further research using longer timeframes and alternative measures of cognitive decline is recommended.
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Aggarwal, N. T., Wilson, R. S., Beck, T. L., Rajan, K. B., de Leon, C. F. M., Evans, D. A., & Everson-Rose, S. A. (2014). Perceived stress and change in cognitive function among adults aged 65 and older. Psychosomatic Medicine, 76, 80–85.
Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions. London, UK: Sage.
Akers, K. G., Martinez-Canabal, A., Restivo, L., Yiu, A. P., De Cristofaro, A., Hsiang, H. L., … Ohira, K. (2014). Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science, 344, 598–602.
Anstey, K. J., Mack, H. A., & Cherbuin, N. (2009). Alcohol consumption as a risk factor for dementia and cognitive decline: Meta-analysis of prospective studies. American Journal of Geriatric Psychiatry, 17, 542–555.
Anstey, K. J., von Sanden, C., Salim, A., & O’Kearney, R. (2007). Smoking as a risk factor for dementia and cognitive decline: A meta-analysis of prospective studies. American Journal of Epidemiology, 166, 367–378.
Baars, M. A. E., Van Boxtel, M. P. J., Dijkstra, J. B., Visser, P. J., Van Den Akker, M., Verhey, F. R. J., & Jolles, J. (2009). Predictive value of mild cognitive impairment for dementia. Dementia and Geriatric Cognitive Disorders, 27, 173–181.
Beckman, N., Waern, M., Gustafson, D., & Skoog, I. (2008). Secular trends in self reported sexual activity and satisfaction in Swedish 70 year olds: Cross sectional survey of four populations, 1971–2001. The BMJ, 337, a279. https://doi.org/10.1136/bmj.a279.
Bedos, M., Portillo, W., & Paredes, R. G. (2018). Neurogenesis and sexual behaviour. Frontiers in Neuroendocrinology. https://doi.org/10.1016/j.yfrne.2018.02.004.
Blaicher, W., Gruber, D., Bieglmayer, C., Blaicher, A. M., Knogler, W., & Huber, J. C. (1999). The role of oxytocin in relation to female sexual arousal. Gynecologic and Obstetric Investigation, 47, 125–126.
Burgess, N., Maguire, E. A., & O’Keefe, J. (2002). The human hippocampus and spatial and episodic memory. Neuron, 35, 625–641.
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193–213.
Campbell, A. (2010). Oxytocin and human social behavior. Personality and Social Psychology Review, 14, 281–295.
Cohen, J. (1992). A power primer. Psychological Bulletin, 112, 155–159.
Cormie, P., Newton, R. U., Taaffe, D. R., Spry, N., Joseph, D., Hamid, M. A., & Galvao, D. A. (2013). Exercise maintains sexual activity in men undergoing androgen suppression for prostate cancer: A randomized controlled trial. Prostate Cancer and Prostatic Diseases, 16, 170–175.
de Jong, T. R., Menon, R., Bludau, A., Grund, T., Biermeier, V., Klampfl, S. M., … Neumann, I. D. (2015). Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study. Psychoneuroendocrinology, 62, 381–388.
Deary, I. J., Corley, J., Gow, A. J., Harris, S. E., Houlihan, L. M., Marioni, R. E., … Starr, J. M. (2009). Age-associated cognitive decline. British Medical Bulletin, 92, 135–152.
Dello Buono, M., Zaghi, P. C., Padoani, W., Scocco, P., Urciuoli, O., Pauro, P., & De Leo, D. (1998). Sexual feelings and sexual life in an Italian sample of 335 elderly 65 to 106-year-olds. Archives of Gerontology and Geriatrics, 26, 155–162.
Deng, W., Aimone, J. B., & Gage, F. H. (2010). New neurons and new memories: How does adult hippocampal neurogenesis affect learning and memory? Nature Reviews Neuroscience, 11, 339–350.
Dupret, D., Fabre, A., Döbrössy, M. D., Panatier, A., Rodríguez, J. J., Lamarque, S., … Abrous, D. N. (2007). Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biology, 5, e214.
Dupret, D., Revest, J. M., Koehl, M., Ichas, F., De Giorgi, F., Costet, P., … Piazza, P. V. (2008). Spatial relational memory requires hippocampal adult neurogenesis. PLoS ONE, 3, e1959.
Galea, L. A. M., Wainwright, S. R., Roes, M. M., Duarte-Guterman, P., Chow, C., & Hamson, D. K. (2013). Sex, hormones and neurogenesis in the hippocampus: Hormonal modulation of neurogenesis and potential functional implications. Journal of Neuroendocrinology, 25, 1039–1061.
Gauthier, S., Reisberg, B., Zaudig, M., Petersen, R. C., Ritchie, K., Broich, K., … Cummings, J. L. (2006). Mild cognitive impairment. The Lancet, 367, 1262–1270.
Glasper, E. R., & Gould, E. (2013). Sexual experience restores age-related decline in adult neurogenesis and hippocampal function. Hippocampus, 23, 303–312.
Glasper, E. R., LaMarca, E. A., Bocarsly, M. E., Fasolino, M., Opendak, M., & Gould, E. (2015). Sexual experience enhances cognitive flexibility and dendritic spine density in the medial prefrontal cortex. Neurobiology of Learning and Memory, 125, 73–79.
Grysman, A., & Hudson, J. A. (2013). Gender differences in autobiographical memory: Developmental and methodological considerations. Developmental Review, 33, 239–272.
Hartmans, C., Comijs, H., & Jonker, C. (2014). Cognitive functioning and its influence on sexual behavior in normal aging and dementia. International Journal of Geriatric Psychiatry, 29, 441–446.
Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. New York, NY: Guilford.
Juster, F. T., & Suzman, R. (1995). An overview of the Health and Retirement Study. Journal of Human Resources, 30, S7–S56.
Kalmbach, D. A., Arnedt, J. T., Pillai, V., & Ciesla, J. A. (2015). The impact of sleep on female sexual response and behavior: A pilot study. Journal of Sexual Medicine, 12, 1221–1232.
Kim, J. I., Lee, J. W., Lee, Y. A., Lee, D. H., Han, N. S., Choi, Y. K., … Han, J. S. (2013). Sexual activity counteracts the suppressive effects of chronic stress on adult hippocampal neurogenesis and recognition memory. Brain Research, 1538, 26–40.
Leuner, B., Glasper, E. R., & Gould, E. (2010). Sexual experience promotes adult neurogenesis in the hippocampus despite an initial elevation in stress hormones. PLoS ONE, 5, e11597.
Lourida, I., Soni, M., Thompson-Coon, J., Purandare, N., Lang, I. A., Ukoumunne, O. C., & Llewellyn, D. J. (2013). Mediterranean diet, cognitive function, and dementia: A systematic review. Epidemiology, 24, 479–489.
Marshall, A. C., Cooper, N. R., Segrave, R., & Geeraert, N. (2015). The effects of long-term stress exposure on aging cognition: A behavioral and EEG investigation. Neurobiology of Aging, 36, 2136–2144.
McArdle, J. J., Smith, J. P., & Willis, R. (2009). Cognition and economic outcomes in the Health and Retirement Survey (No. w15266). National Bureau of Economic Research.
Mercer, C. H., Tanton, C., Prah, P., Erens, B., Sonnenberg, P., Clifton, S., … Datta, J. (2013). Changes in sexual attitudes and lifestyles in Britain through the life course and over time: Findings from the national surveys of sexual attitudes and lifestyles (Natsal). The Lancet, 382, 1781–1794.
Mielke, M. M., Vemuri, P., & Rocca, W. A. (2014). Clinical epidemiology of Alzheimer’s disease: Assessing sex and gender differences. Clinical Epidemiology, 6, 37–48.
Opdebeeck, C., Martyr, A., & Clare, L. (2016). Cognitive reserve and cognitive function in healthy older people: A meta-analysis. Aging, Neuropsychology, and Cognition, 23, 40–60.
Opendak, M., Briones, B. A., & Gould, E. (2016). Social behavior, hormones and adult neurogenesis. Frontiers in Neuroendocrinology, 41, 71–86.
Owen, S. F., Tuncdemir, S. N., Bader, P. L., Tirko, N. N., Fishell, G., & Tsien, R. W. (2013). Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. Nature, 500, 458–462.
Padoani, W., Buono, M. D., Marietta, P., Scocco, P., Zaghi, P. C., & De Leo, D. (2000). Influence of cognitive status on the sexual life of 352 elderly Italians aged 65–105 years. Gerontology, 46, 258–265.
Plassman, B. L., Williams, J. W., Burke, J. R., Holsinger, T., & Benjamin, S. (2010). Systematic review: Factors associated with risk for and possible prevention of cognitive decline in later life. Annals of Internal Medicine, 153, 182–193.
Prakash, R. S., Voss, M. W., Erickson, K. I., & Kramer, A. F. (2015). Physical activity and cognitive vitality. Annual Review of Psychology, 66, 769–797.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013). The global prevalence of dementia: A systematic review and meta-analysis. Alzheimer’s & Dementia, 9, 63–75.
Rubin, D. B. (1987). Multiple imputation for nonresponse in surveys. New York, NY: Wiley.
Salthouse, T. A. (2009). When does age-related cognitive decline begin? Neurobiology of Aging, 30, 507–514.
Sofi, F., Valecchi, D., Bacci, D., Abbate, R., Gensini, G. F., Casini, A., & Macchi, C. (2011). Physical activity and risk of cognitive decline: A meta-analysis of prospective studies. Journal of Internal Medicine, 269, 107–117.
Spritzer, M. D., Curtis, M. G., DeLoach, J. P., Maher, J., & Shulman, L. M. (2016). Sexual interactions with unfamiliar females reduce hippocampal neurogenesis among adult male rats. Neuroscience, 318, 143–156.
Squire, L. R. (1992). Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans. Psychological Review, 99, 195–231.
Steptoe, A., Breeze, E., Banks, J., & Nazroo, J. (2013). Cohort profile: The English Longitudinal Study of Ageing. International Journal of Epidemiology, 42, 1640–1648.
Valls-Pedret, C., Sala-Vila, A., Serra-Mir, M., Corella, D., de la Torre, R., Martínez-González, M. Á., … Estruch, R. (2015). Mediterranean diet and age-related cognitive decline: A randomized clinical trial. JAMA Internal Medicine, 175, 1094–1103.
Veening, J. G., De Jong, T. R., Waldinger, M. D., Korte, S. M., & Olivier, B. (2015). The role of oxytocin in male and female reproductive behavior. European Journal of Pharmacology, 753, 209–228.
Wright, H., & Jenks, R. A. (2016). Sex on the brain! Associations between sexual activity and cognitive function in older age. Age and Ageing, 45, 313–317.
Wright, H., Jenks, R. A., & Demeyere, N. (2017). Frequent sexual activity predicts specific cognitive abilities in older adults. The Journals of Gerontology: Series B. https://doi.org/10.1093/geronb/gbx065.
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Allen, M.S. Sexual Activity and Cognitive Decline in Older Adults. Arch Sex Behav 47, 1711–1719 (2018). https://doi.org/10.1007/s10508-018-1193-8
- Cognitive function
- Episodic memory
- Sexual health
- Social behavior