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Homosexual Sons and the Fraternal Birth Order Effect: The Role of Elevated Maternal Intrauterine Testosterone

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The Original Article was published on 12 June 2017

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References

  • Anello, A., Reichenberg, A., Luo, X., Schmeidler, J., Hollander, E., Smith, C. J., … Silverman, J. M. (2009). Brief report: Parental age and the sex ratio in autism. Journal of Autism and Developmental Disorders, 39, 1487–1492. https://doi.org/10.1007/s10803-009-0755-y.

  • Bailey, J. M., Vasey, P. L., Diamond, L. M., Breedlove, S. M., Villain, E., & Epprecht, M. (2016). Sexual orientation, controversy, and science. Psychological Science in the Public Interest, 17, 45–101.

    Article  PubMed  Google Scholar 

  • Bailey, J. M., Willerman, L., & Parks, C. (1991). A test of the maternal stress theory of human male homosexuality. Archives of Sexual Behavior, 20, 277–293.

    Article  PubMed  Google Scholar 

  • Baischer, W., Koinig, G., Hartmann, B., Huber, J., & Langer, G. (1995). Hypothalamic-pituitary-gonadal axis in depressed premenopausal women: Elevated blood testosterone concentrations compared to normal controls. Psychoneuroendocrinology, 20, 553–559.

    Article  PubMed  Google Scholar 

  • Baron-Cohen, S., Auyeung, B., Norgaard-Pedersen, B., Hougaard, D. M., Abdallah, M. W., Melgaard, L., … Lombardo, M. V. (2015). Elevated fetal steroidogenic activity in autism. Molecular Psychiatry, 20, 369–376. https://doi.org/10.1038/mp.2014.48.

  • Bejerot, S., Humble, M. B., & Gardner, A. (2011). Endocrine disruptors, the increase of autism spectrum disorder and its comorbidity with gender identity disorder—a hypothetical association. International Journal of Andrology, 34, e350–2605. https://doi.org/10.1111/j.1365-2605.2011.01149.x.

    Article  PubMed  Google Scholar 

  • Blanchard, R. (1985). Typology of male-to-female transsexualism. Archives of Sexual Behavior, 14, 247–261.

    Article  PubMed  Google Scholar 

  • Blanchard, R. (2017). Fraternal birth order, family size, and male homosexuality: Meta-analysis of studies spanning 25 years. Archives of Sexual Behavior. https://doi.org/10.1007/s10508-017-1007-4.

    Google Scholar 

  • Bogaert, A. F. (2006). Biological versus nonbiological older brothers and men’s sexual orientation. Proceedings of the National Academy of Sciences of the USA, 103, 10771–10774.

    Article  PubMed  PubMed Central  Google Scholar 

  • Camperio Ciani, A., & Pellizzari, E. (2012). Fecundity of paternal and maternal non-parental female relatives of homosexual and heterosexual men. PLoS ONE, 7(12), e51088. https://doi.org/10.1371/journal.pone.0051088.

    Article  PubMed  PubMed Central  Google Scholar 

  • Carlsen, S. M., Jacobsen, G., & Romundstad, P. (2006). Maternal testosterone levels during pregnancy are associated with offspring size at birth. European Journal of Endocrinology, 155, 365–370.

    Article  PubMed  Google Scholar 

  • Cheslack-Postava, K., Susser, E., Liu, K., & Bearman, P. S. (2015). Can sibling sex ratios be used as a valid test for the prenatal androgen hypothesis of autism spectrum disorders? PLoS ONE, 10(10), e0141338.

    Article  PubMed  PubMed Central  Google Scholar 

  • de Vries, A. L., Noens, I. L., Cohen-Kettenis, P. T., van Berckelaer-Onnes, I. A., & Doreleijers, T. A. (2010). Autism spectrum disorders in gender dysphoric children and adolescents. Journal of Autism and Developmental Disorders, 40, 930–936.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dörner, G., Schenk, B., Schmiedel, B., & Ahrens, L. (1983). Stressful events in prenatal life of bi- and homosexual men. Experimental and Clinical Endocrinology, 81, 83–87. https://doi.org/10.1055/s-0029-1210210.

    Article  PubMed  Google Scholar 

  • Goldberg, M., & Lichten, J. (1995). High androgen levels in chronic fatigue patients. Journal of Clinical Endocrinology and Metabolism, 80, 3390–3391. https://doi.org/10.1210/jcem.80.11.7593460.

    PubMed  Google Scholar 

  • Hines, M. (2011). Prenatal endocrine influences on sexual orientation and on sexually differentiated childhood behavior. Frontiers in Neuroendocrinology, 32, 170–182. https://doi.org/10.1016/j.yfrne.2011.02.006.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hines, M., Constantinescu, M., & Spencer, D. (2015). Early androgen exposure and human gender development. Biology of Sex Differences, 6(3). https://doi.org/10.1186/s13293-015-0022-1.

  • James, W. H. (1996). Evidence that mammalian sex ratios at birth are partially controlled by parental hormone levels at the time of conception. Journal of Theoretical Biology, 180, 271–286.

    Article  PubMed  Google Scholar 

  • James, W. H. (2004). Further evidence that mammalian sex ratios at birth are partially controlled by parental hormone levels around the time of conception. Human Reproduction, 19, 1250–1256.

    Article  PubMed  Google Scholar 

  • James, W. H. (2008a). Further evidence that some male-based neurodevelopmental disorders are associated with high intrauterine testosterone concentrations. Developmental Medicine and Child Neurology, 50, 15–18.

    Article  PubMed  Google Scholar 

  • James, W. H. (2008b). Evidence that mammalian sex ratios at birth are partially controlled by parental hormone levels around the time of conception. Journal of Endocrinology, 198, 3–15. https://doi.org/10.1677/JOE-07-0446.

    Article  PubMed  Google Scholar 

  • James, W. H. (2010). Behavioural and biological determinants of human sex ratio at birth. Journal of Biosocial Science, 42, 587.

    Article  PubMed  Google Scholar 

  • James, W. H. (2013). Evolution and the variation of mammalian sex ratios at birth: Reflections on Trivers and Willard (1973). Journal of Theoretical Biology, 334, 141–148.

    Article  PubMed  Google Scholar 

  • James, W. H. (2014). An update on the hypothesis that one cause of autism is high intrauterine levels of testosterone of maternal origin. Journal of Theoretical Biology, 355, 33–39.

    Article  PubMed  Google Scholar 

  • James, W. H. (2015). Hypothesis: High levels of maternal adrenal androgens are a major cause of miscarriage and other forms of reproductive suboptimality. Journal of Theoretical Biology, 364, 316–320.

    Article  PubMed  Google Scholar 

  • James, W. H. (2016). The sex ratio of the sibs of probands diagnosed with autism. Journal of Theoretical Biology, 400, 154–157.

    Article  PubMed  Google Scholar 

  • Kemper, T. D. (1990). Social structure and testosterone: Explorations of the socio-bio-social chain. New Brunswick, NJ: Rutgers University Press.

    Google Scholar 

  • MacCulloch, M. J., & Waddington, J. L. (1981). Neuroendocrine mechanisms and the aetiology of male and female homosexuality. British Journal of Psychiatry, 139, 341–345.

    Article  PubMed  Google Scholar 

  • Manikkam, M., Crespi, E. J., Doop, D. D., Herkimer, C., Lee, J. S., Yu, S., … Padmanabhan, V. (2004). Fetal programming: Prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep. Endocrinology, 145, 790–798. https://doi.org/10.1210/en.2003-0478.

  • Mann, J. R., McDermott, S., Bao, H., Hardin, J., & Gregg, A. (2010). Pre-eclampsia, birth weight, and autism spectrum disorders. Journal of Autism and Developmental Disorders, 40, 548–554. https://doi.org/10.1007/s10803-009-0903-4.

    Article  PubMed  Google Scholar 

  • Meek, L. R., Schulz, K. M., & Keith, C. A. (2006). Effects of prenatal stress on sexual partner preference in mice. Physiology & Behavior, 89, 133–138.

    Article  Google Scholar 

  • Mouridsen, S. E., & Hauschild, K. (2010). The sex ratio of siblings of individuals with a history of developmental language disorder. Logopedics Phoniatrics Vocology, 35, 144–148.

    Article  Google Scholar 

  • Mouridsen, S. E., Rich, B., & Isager, T. (2010). Sibling sex ratio of individuals diagnosed with autism spectrum disorder as children. Developmental Medicine and Child Neurology, 52, 289–292.

    Article  PubMed  Google Scholar 

  • Mouridsen, S. E., Rich, B., & Isager, T. (2016). The sex ratio of full and half siblings of people diagnosed with ADHD in childhood and adolescence: A Danish nationwide register-based cohort study. Journal of Attention Disorders, 20, 1017–1022.

    Article  PubMed  Google Scholar 

  • Parner, E. T., Baron-Cohen, S., Lauritsen, M. B., Jorgensen, M., Schieve, L. A., Yeargin-Allsopp, M., et al. (2012). Parental age and autism spectrum disorders. Annals of Epidemiology, 22, 143–150. https://doi.org/10.1016/j.annepidem.2011.12.006.

    Article  PubMed  PubMed Central  Google Scholar 

  • Popova, N. K., Morozova, M. V., & Amstislavskaya, T. G. (2011). Prenatal stress and ethanol exposure produces inversion of sexual partner preference in mice. Neuroscience Letters, 489, 48–52. https://doi.org/10.1016/j.neulet.2010.11.064.

    Article  PubMed  Google Scholar 

  • Powell, L. H., Lovallo, W. R., Matthews, K. A., Meyer, P., Midgley, A. R., Baum, A., et al. (2002). Physiologic markers of chronic stress in premenopausal, middle-aged women. Psychosomatic Medicine, 64, 502–509.

    Article  PubMed  Google Scholar 

  • Rieske, R. D., Matson, J. L., Beighley, J. S., Cervantes, P. E., Goldin, R. L., & Jang, J. (2015). Comorbid psychopathology rates in children diagnosed with autism spectrum disorders according to the DSM-IV-TR and the proposed DSM-5. Developmental Neurorehabilitation, 18, 218–223. https://doi.org/10.3109/17518423.2013.790519.

    Article  PubMed  Google Scholar 

  • Roos, A., Robertson, F., Lochner, C., Vythilingum, B., & Stein, D. J. (2011). Altered prefrontal cortical function during processing of fear-relevant stimuli in pregnancy. Behavioural Brain Research, 222, 200–205. https://doi.org/10.1016/j.bbr.2011.03.055.

    Article  PubMed  Google Scholar 

  • Semenyna, S. W., Petterson, L. J., VanderLaan, D. P., & Vasey, P. L. (2017). A comparison of the reproductive output among the relatives of Samoan androphilic fa’afafine and gynephilic men. Archives of Sexual Behavior, 46, 87–93. https://doi.org/10.1007/s10508-016-0765-8.

    Article  PubMed  Google Scholar 

  • Spiegelhalter, D. (2015). Sex by numbers: What statistics can tell us about sexual behaviour. London: Profile Books.

    Google Scholar 

  • Trivers, R. L., & Willard, D. E. (1973). Natural selection of parental ability to vary the sex ratio of offspring. Science, 179, 90–92.

    Article  PubMed  Google Scholar 

  • VanderLaan, D. P., Leef, J. H., Wood, H., Hughes, S. K., & Zucker, K. J. (2015). Autism spectrum disorder risk factors and autistic traits in gender dysphoric children. Journal of Autism and Developmental Disorders, 45, 1742–1750.

    Article  PubMed  Google Scholar 

  • Voegtline, K. M., Costigan, K. A., Kivlighan, K. T., Henderson, J. L., & DiPietro, J. A. (2013). Sex-specific associations of maternal prenatal testosterone levels with birth weight and weight gain in infancy. Journal of Developmental Origins of Health and Disease, 4, 280–284. https://doi.org/10.1017/S2040174413000135.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

WHJ is indebted to Sir David Spiegelhalter and to Professor Robert Trivers for their generous assessments of his hypothesizing.

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Authors and Affiliations

  1. Galton Laboratory, Department of Genetics, Evolution and Environment, University College London, London, WC1E 6HH, UK

    William H. James

  2. Paediatric Department, University of Malta Medical School, Msida, Malta

    Victor Grech

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  1. William H. James
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  2. Victor Grech
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Correspondence to William H. James.

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James, W.H., Grech, V. Homosexual Sons and the Fraternal Birth Order Effect: The Role of Elevated Maternal Intrauterine Testosterone. Arch Sex Behav 47, 33–36 (2018). https://doi.org/10.1007/s10508-017-1113-3

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  • DOI: https://doi.org/10.1007/s10508-017-1113-3

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